PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Zpz_sc02366.1.g00080.1.sm.mk
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Chloridoideae; Zoysieae; Zoysiinae; Zoysia
Family bHLH
Protein Properties Length: 401aa    MW: 43737.9 Da    PI: 6.3308
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Zpz_sc02366.1.g00080.1.sm.mkgenomeZGDView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH352.5e-11180237155
                                   CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC.....TTS-.STCHHHHHHHHHHHHHHH CS
                           HLH   1 rrrahnerErrRRdriNsafeeLrellPkas..kapskK.lsKaeiLekAveYIksLq 55 
                                   +rr+h ++Er+RR+++N+ +  Lr+l+P ++  +a+ +   + a+i   A+e I++L+
  Zpz_sc02366.1.g00080.1.sm.mk 180 QRRTHIAVERNRRRQMNEYLRILRSLMPGSYvqRARPGIvGDQASIIGGAIELIRELE 237
                                   79***************************666977777889**************995 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000832.23E-10178241No hitNo description
Gene3DG3DSA:4.10.280.105.6E-12178240IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474591.28E-12179250IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088814.322179236IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000105.6E-9180237IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003539.1E-5185242IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd048730.00445340398No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 401 aa     Download sequence    Send to blast
MSAIKRMDKQ KATTTHSHLD SFAPEEEHSA ESGGGAEMVD YMLSQADHPA SQPTEGQSHQ  60
QVSFDKLRFS DVLEFADFGP KLAINQVDGG EDNDGYLFRF QPLPSHPEAP PRGDAAGQQH  120
HHVEQQEGSK KTADGGVSDS TTLVELADGG GREEKGGGQG KSGRRKRPRT VKTSEEVESQ  180
RRTHIAVERN RRRQMNEYLR ILRSLMPGSY VQRARPGIVG DQASIIGGAI ELIRELEHLI  240
QCLDSQKRRR LYGGSDDAPR LVVDPAGAGA PASILQHQPQ PPPPPSFFPP SLPFPTASGG  300
SGSDVQILDL DVAEGLREAV AENKSCLADI EVRAVGADAM IKILSRRRPG QLIRTIAALE  360
EMQMSILHTN ITTIEQTVLY SFNVKGKITG KEESEQYAVK C
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1149157GGREEKGGG
2246250KRRRL
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapZpz_sc02366.1.g00080.1.sm.mk
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_025805324.11e-157transcription factor FAMA isoform X1
SwissprotQ56YJ84e-90FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A0A9GYP11e-164A0A0A9GYP1_ARUDO; FMA
STRINGPavir.J04021.1.p1e-158(Panicum virgatum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP95023340
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.11e-84bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]