PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Zmw_sc03406.1.g00090.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Chloridoideae; Zoysieae; Zoysiinae; Zoysia
Family bHLH
Protein Properties Length: 513aa    MW: 55590.5 Da    PI: 6.6004
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Zmw_sc03406.1.g00090.1genomeZGD-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH40.74.2e-13311362155
                                   CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                           HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                                   +rr+h ++Er+RR+++N+ +  Lr+l+P +   + ++   a+i   A+e+I++L+
  Zmw_sc03406.1.g00090.1.am.mk 311 QRRTHIAVERNRRRQMNEYLRILRSLMPGS---YVQRAHQASIIGGAIEFIRELE 362
                                   79****************************...9******************996 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000833.15E-12309366No hitNo description
Gene3DG3DSA:4.10.280.102.1E-13309365IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088815.313310361IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474591.44E-15310375IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.9E-10311362IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003538.8E-9316367IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010377Biological Processguard cell fate commitment
GO:0045597Biological Processpositive regulation of cell differentiation
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051782Biological Processnegative regulation of cell division
GO:0005634Cellular Componentnucleus
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 513 aa     Download sequence    Send to blast
MSIDRKSWGK KEDRSVILDA FSATIINSLL FFRSAHVARR PPSIGHSLGG FPSLAVSALL  60
ACFTVNVSER CEAPLHTNTN QSLPSFSACV RACVFLASLH LDPFLPPLAD RAIPACRELA  120
AAGACVHTFG RVSLRACDVP SKATTTHSHL DSFAPEEEHS AESGGGAEMV DYMLSQADHP  180
ASQPTEGQSH QQVSFDKLRF SDVLEFADFG PKLAINQVDG GEDDDGYLFR FQPLPSLPAA  240
PPRGDAAGQQ HHHVEQQEGS KKTADGGISD STTLVEQADG GGREEKGGGQ GKSGRRKRPR  300
TVKTSEEVES QRRTHIAVER NRRRQMNEYL RILRSLMPGS YVQRAHQASI IGGAIEFIRE  360
LEHLIQCLDS QKRRRLYGGS DDAPRLVVDP AGAGAPASIQ QHQPQPPPPP SFFPPSLPFP  420
TASGGSGSDV QILDLDVAEG LREAVAENKS CLADIEVRAV GADAMIKILS RRRPGQLIGT  480
IAALEEMQMS ILHTNITTIE QTVLYSFNVK DYT
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1280288GGREEKGGG
2371375KRRRL
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_025805325.11e-158transcription factor FAMA isoform X2
SwissprotQ56YJ81e-88FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A0A9GYP11e-165A0A0A9GYP1_ARUDO; FMA
STRINGPavir.J04021.1.p1e-158(Panicum virgatum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP95023340
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]