PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID GRMZM2G041701_P01
Common NameLOC100279729, ZEAMMB73_265177
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea
Family E2F/DP
Protein Properties Length: 462aa    MW: 50278.2 Da    PI: 4.8253
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
GRMZM2G041701_P01genomeMaizeSequenceView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP82.73e-26145209170
            E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwk 70 
                        r+++sL+llt+kf++ll+++++gi++ln++a+ L   +v  ++RRiYDi+NVLe+++liek+ kn+irwk
  GRMZM2G041701_P01 145 RYDNSLGLLTKKFINLLKQAPDGILDLNNAAEVL---EV--QKRRIYDITNVLEGIGLIEKTLKNRIRWK 209
                        689*******************************...99..****************************8 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.6E-27143211IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.0E-34145210IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467856.53E-18145208IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.1E-23147209IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146603.34E-49220326No hitNo description
SuperFamilySSF1440742.56E-34222326No hitNo description
PfamPF164215.8E-33225324IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 462 aa     Download sequence    Send to blast
MSGVGSGRPP AAQKILQSLR PPLSFSTPSR PPFAAPDDYH RFPTPAAATS PAATSGGVGA  60
GAAPPDTVEE GLVIRTPLKR KATSEENAAA DSSSCIITSP MLTPVSAKTV KASKAKAKNS  120
KTGPQTPTSN VGSPLNPPTP VGTCRYDNSL GLLTKKFINL LKQAPDGILD LNNAAEVLEV  180
QKRRIYDITN VLEGIGLIEK TLKNRIRWKA LDDSSVQLDN GISALQAEVE NLSLQEQALD  240
ERISDIREKL RGLTEDENNQ RWLYVTEDDI KGLPSFQNET LIAIKAPHGT TLEVPDPDEA  300
GDYLQRRYRI VLRSTMGPID VYLVSQFDEK FEELGGVATP AKHSNVPRHQ PAEDFNTSYA  360
GQSSTLMGVA HDAQHSQKIP QDPSALHDFG GMTRISPSDV HTDSDYWLLT EGDVSMTDMW  420
KTEQAQWDEM DFLSEDVVTP RAHNQQLVTV DGPHMEVPST DP
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-22137211274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Zm.12490.0meristem| ovary| shoot| tassel
Expression -- Microarray ? help Back to Top
Source ID
Expression AtlasGRMZM2G041701
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapGRMZM2G041701_P01
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT0547720.0BT054772.1 Zea mays full-length cDNA clone ZM_BFb0035J13 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001146160.10.0transcription factor E2F3
SwissprotQ9FNY01e-129E2FA_ARATH; Transcription factor E2FA
TrEMBLB7ZZN00.0B7ZZN0_MAIZE; Transcription factor E2F
TrEMBLK4JEA30.0K4JEA3_MAIZE; E2F-DP-type transcription factor (Fragment)
STRINGGRMZM2G041701_P010.0(Zea mays)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP62537148
Representative plantOGRP12251749
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-124E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]