PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AC233850.1_FGP005
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea
Family E2F/DP
Protein Properties Length: 479aa    MW: 52497.2 Da    PI: 5.3392
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AC233850.1_FGP005genomeMaizeSequenceView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP83.22e-26146210170
            E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwk 70 
                        r+++sL+llt+kf++ll+++++gi++ln++a++L   +v  ++RRiYDi+NVLe+++liek+ kn+irwk
  AC233850.1_FGP005 146 RYDSSLGLLTKKFINLLKQAPDGILDLNNAAETL---EV--QKRRIYDITNVLEGIGLIEKTLKNRIRWK 210
                        6899******************************...99..****************************8 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.2E-27144212IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.16E-17146209IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.3E-34146211IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023197.7E-24148210IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440742.17E-25242325No hitNo description
PfamPF164212.5E-25244323IPR032198E2F transcription factor, CC-MB domain
CDDcd146603.30E-39244325No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 479 aa     Download sequence    Send to blast
MSGVGSGRPP AAQKILQSLR PPLSFATPSR SPFAAPDDYH RFPTPAAATA PAATSGGVGA  60
GAPPRDTIEE GLFIRTPLKR KATSEENDAA AEPSDCIITS PMPTSVSGKT VKASKAKAKN  120
SKTGPQTPTS NVGSPLNPPT PVGTCRYDSS LGLLTKKFIN LLKQAPDGIL DLNNAAETLE  180
VQKRRIYDIT NVLEGIGLIE KTLKNRIRWK ALDDSSVQLD NGISALQVLT KILSNQVLCI  240
PFSDMREKLR GLTEDENNKR WLYVTEDDIK GLPSFQNETL IAIKAPHGTT LEVPDPDEAG  300
DYLQRRYRIV LRSTMGPIDV YLVSQFDEKF EELGGVATPV KHSSVPRHQP AEDFNTYAGQ  360
SSTPMDVAHD VQHGQKIPQD PSALHDFGGM TRISPSDVHT DSDYWLLTEG DVSMTDMWKT  420
GRILDDHALR CLNFLTWKIE EVQWDQMDFL SEDVVTPRAH NQQPVTVDGP HMEVPSMDP
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A6e-23138212274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Zm.413740.0meristem| pollen| shoot
Expression -- Microarray ? help Back to Top
Source ID
Expression AtlasAC233850.1_FG005
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapAC233850.1_FGP005
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankEU9713280.0EU971328.1 Zea mays clone 362179 transcription factor E2F3 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001151586.20.0transcription factor E2F3
SwissprotQ9FNY01e-117E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A1D6HA420.0A0A1D6HA42_MAIZE; Transcription factor E2FB
TrEMBLA0A3L6EKC20.0A0A3L6EKC2_MAIZE; Transcription factor E2FA
STRINGAC233850.1_FGP0050.0(Zea mays)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP62537148
Representative plantOGRP12251749
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.31e-110E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]