PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID GSVIVT01033931001
Common NameLOC100249486, VIT_08s0007g02510
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; rosids incertae sedis; Vitales; Vitaceae; Vitis
Family E2F/DP
Protein Properties Length: 467aa    MW: 51279.4 Da    PI: 4.654
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
GSVIVT01033931001genomeGenoscopeView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.22.5e-27144209171
            E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                        r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  GSVIVT01033931001 144 RYDSSLGLLTKKFINLIKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 209
                        6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.2E-29141211IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467854.99E-17144207IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.0E-34144209IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.3E-24146209IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.34E-50220326No hitNo description
SuperFamilySSF1440741.33E-34221326No hitNo description
PfamPF164212.5E-34225324IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 467 aa     Download sequence    Send to blast
MSGPRAPTRS APPPPSSGQI LRPMKRHLPF TSTKPPFVPP DDYHRFSSAD AHGVANHEPE  60
GIVVKSPQLK RKSAMDDNEV GSSEWTASPG YADAGNSPFR TPVSGKGGRI YSKSKVSKGN  120
VCGPQTPVSN AGSPSTLTPA GNCRYDSSLG LLTKKFINLI KHAEDGILDL NKAAETLEVQ  180
KRRIYDITNV LEGIGLIEKK LKNRIRWKGL DVSRPGEVDD DVTILQAEVE NLSLEERRLD  240
DHIREMQEKL RDLSEDENNQ KWLFVTEDDI KGLPCFQNET LIAIKAPHGT TLEVPDPDEA  300
VDYPQRRYRI VLRSTMGPID VYLVSQFEEK FEEMNGTPPP LSFPLASSSG SNENPSTEVV  360
IADSSGKELE PQDGYQMCSD LTASQEFIGG IMKIVPDVDS DADYWLRSDA EVSITDMWKT  420
DSYVEWNGVD MLNAEFGMAD VSTPLPQTPP SGLTEGPSTA VNPTHR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A5e-24139210274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Vvi.170060.0leaf
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAM4429321e-135AM442932.2 Vitis vinifera contig VV78X220351.11, whole genome shotgun sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010654143.10.0PREDICTED: transcription factor E2FA isoform X2
SwissprotQ9FNY01e-172E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A438JAG60.0A0A438JAG6_VITVI; Transcription factor E2FA
TrEMBLD7TH520.0D7TH52_VITVI; Uncharacterized protein
STRINGVIT_08s0007g02510.t010.0(Vitis vinifera)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP12251749
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-170E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]