PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID 678451793
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lentibulariaceae; Utricularia
Family E2F/DP
Protein Properties Length: 480aa    MW: 53382.1 Da    PI: 4.6067
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
678451793genomeUGSPView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP80.21.8e-25146207671
    E2F_TDP   6 LrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                L+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  678451793 146 LGLLTKKFINLIKHAEDGILDLNKAADTL---EV-VQKRRIYDITNVLEGIGLIEKKLKNRIQWKG 207
                99***************************...55.5****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM013726.1E-29141207IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.1E-25145208IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.58E-15146205IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023193.3E-22146207IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146602.28E-44218324No hitNo description
SuperFamilySSF1440741.94E-32220324No hitNo description
PfamPF164213.2E-32223322IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 480 aa     Download sequence    Send to blast
MQPAEKQPLR RQLMVDSKRP PFGRGVGGEY HHFVDDEMRN PPRDFDEGIV VRTPPALKRK  60
GGKPESELES GKLGGSSSVS PLQVCNQTPP TVKSGKNQKV PRTTKPSKIG PQVPVTNIGS  120
PSGNNLTPGP CRYDSSLVVK IHLTVLGLLT KKFINLIKHA EDGILDLNKA ADTLEVVQKR  180
RIYDITNVLE GIGLIEKKLK NRIQWKGIDV HRPGDDVESL PSLQMDVENL NTEESTLDER  240
IREMQEKLRG LSEDDNNKKW LFVTEEDIKG LPCFQNETLI AIKAPHGTTL EVPDPDEAVD  300
YPHRRYRIVL RSTMGPIDVY LVSQFVENFD DNNASEMQES APEMVLTEEY PSNPIAVDDI  360
KGNEFDLQQI EPQRICSDAT TSQDFSSGIM KIIPDVDDEA DYWLLSDADT SLTNIWGVES  420
GVDWNSLETV LEDQLMLCIP TSPTPSLPPP PAGHLPCDIS QHQNNPTGTT TPSTTSENRI
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A5e-25142208874PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Cis-element ? help Back to Top
SourceLink
PlantRegMap678451793
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011090314.10.0transcription factor E2FB isoform X1
SwissprotQ9FV711e-123E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A2R6P7351e-177A0A2R6P735_ACTCH; Transcription factor E2FB like
STRINGMigut.N02463.1.p1e-179(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-123E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]