PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID 678296180
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lentibulariaceae; Utricularia
Family E2F/DP
Protein Properties Length: 345aa    MW: 38794.9 Da    PI: 9.0954
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
678296180genomeUGSPView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP74.98.1e-242792171
    E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
               rk+ksL+ll+++fl+l++++  +++ l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  678296180 27 RKQKSLGLLCSNFLSLYNREGVETIGLDDAASRL---GV--ERRRIYDIVNVLESVGILARKAKNRYSWKG 92
               79*****************999************...**..****************************98 PP

2E2F_TDP711.4e-22137207171
    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                rkeksL+lltq+f+kl+ +++ ++++l+++ak L       k+RR+YDi+NVL+++n iek     ++k+++rw g
  678296180 137 RKEKSLGLLTQNFIKLFLCTDMDMISLDDAAKLL---LA--KVRRLYDIANVLSSMNFIEKthhaeTRKPAFRWLG 207
                79********************************...55..89*********************999*******87 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.1E-262593IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.8E-282792IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467857.33E-162790IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.0E-202892IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.2E-25135209IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.81E-13136195IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.8E-29137207IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.5E-18138207IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 345 aa     Download sequence    Send to blast
MALPPQTAAS TATVSFESKC REVPYCRKQK SLGLLCSNFL SLYNREGVET IGLDDAASRL  60
GVERRRIYDI VNVLESVGIL ARKAKNRYSW KGFGAIPKAL EDLRVASDDD DEFCSDFSSS  120
SQNEKAGSCS VSLGENRKEK SLGLLTQNFI KLFLCTDMDM ISLDDAAKLL LAKVRRLYDI  180
ANVLSSMNFI EKTHHAETRK PAFRWLGFNS STGSTVFAES SQLTVSKKRM FGTDITNTIG  240
KRHKLNGEDV QFVKPHNPKQ VKNEVDEKTT VPKNYQFGPF APVNVSKIGS SEENRNRDVD  300
WDNMAAAYRP QYQNQALKDL FSHFVEAWKS WYSEAAGKNT KMYLS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A4e-34271994228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMap678296180
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011071778.11e-169E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ41e-106E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A2G9GKB51e-161A0A2G9GKB5_9LAMI; Transcription factor E2F/dimerization partner (TDP)-like protein
STRINGMigut.I00063.1.p1e-151(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA25222457
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.23e-98DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]