PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Tp57577_TGAC_v2_mRNA3667
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Trifolieae; Trifolium
Family HSF
Protein Properties Length: 382aa    MW: 42900 Da    PI: 4.5325
Description HSF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Tp57577_TGAC_v2_mRNA3667genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HSF_DNA-bind111.17.7e-35481392102
                               HHHHHHHHHCTGGGTTTSEESSSSSEEEES-HHHHHHHTHHHHSTT--HHHHHHHHHHTTEEE---SSBTTTTXTTSEEEEESXX CS
              HSF_DNA-bind   2 FlkklyeiledeelkeliswsengnsfvvldeeefakkvLpkyFkhsnfaSFvRQLnmYgFkkvkdeekkskskekiweFkhksF 86 
                               Fl+k+++++ed+++++++sws   nsfvv+d ++f++++Lp+yFkhsnf+SFvRQLn+YgF+kv+ ++         weF+++ F
  Tp57577_TGAC_v2_mRNA3667  48 FLTKTFDVVEDPSTDSIVSWSGARNSFVVWDLHKFSTTILPRYFKHSNFSSFVRQLNTYGFRKVDPDR---------WEFANEGF 123
                               9********************999*****************************************999.........******** PP

                               XXXXXXXXXXXXXXXX CS
              HSF_DNA-bind  87 kkgkkellekikrkks 102
                                +g+++ll++ikr+++
  Tp57577_TGAC_v2_mRNA3667 124 LAGQRNLLKTIKRRRN 139
                               *************987 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS512575122No hitNo description
Gene3DG3DSA:1.10.10.101.3E-3644137IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.4E-3344137IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM004151.7E-5844137IPR000232Heat shock factor (HSF)-type, DNA-binding
PfamPF004472.8E-3048137IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000561.2E-184871IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000561.2E-188698IPR000232Heat shock factor (HSF)-type, DNA-binding
PROSITE patternPS00434087111IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000561.2E-1899111IPR000232Heat shock factor (HSF)-type, DNA-binding
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009644Biological Processresponse to high light intensity
GO:0010200Biological Processresponse to chitin
GO:0010286Biological Processheat acclimation
GO:0034605Biological Processcellular response to heat
GO:0034620Biological Processcellular response to unfolded protein
GO:0042542Biological Processresponse to hydrogen peroxide
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0071456Biological Processcellular response to hypoxia
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 382 aa     Download sequence    Send to blast
MNGIQVKEEE ILAYASVGST SCSPSSSSGS NLTPKPMEGL HEIGPPPFLT KTFDVVEDPS  60
TDSIVSWSGA RNSFVVWDLH KFSTTILPRY FKHSNFSSFV RQLNTYGFRK VDPDRWEFAN  120
EGFLAGQRNL LKTIKRRRNV TQSQAMQQET GGGACIELGE YGLEGEIERL RRDRAVLMAE  180
IVKLRQQQHN SRDQLSAMEA RLLITEKKHQ QMMTFLAKAL SNQSFIQQLA NNRELKGVEM  240
KRKRRLTASS SLENLQNDSA TMMTVPIESV VDYSSQEQQE GLTTIESEME TLLNAYDNES  300
SSEIKDYSTL TSVPSAKNES NLGDTVWEDL LNQELVGGNP EDEVVIGELS RIDVPVEDLV  360
EKNDDWTVDL QNLVDQMGFE P*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
2ldu_A4e-254613718120Heat shock factor protein 1
5d5u_B5e-254613727129Heat shock factor protein 1
5d5v_B5e-254613727129Heat shock factor protein 1
5d5v_D5e-254613727129Heat shock factor protein 1
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1130136LKTIKRR
2168173RLRRDR
Functional Description ? help Back to Top
Source Description
UniProtDNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. {ECO:0000250}.
UniProtTranscriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Involved in heat stress responses. Seems to be involved in other environmental stress responses. Activates ascorbate peroxidase 2 (APX2) in addition to several heat shock protein (HSPs). {ECO:0000269|PubMed:16649111, ECO:0000269|PubMed:17059409, ECO:0000269|PubMed:17085506}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapTp57577_TGAC_v2_mRNA3667
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By heat stress, high light and hydrogen peroxide (H(2)O(2)). {ECO:0000269|PubMed:16649111, ECO:0000269|PubMed:17059409, ECO:0000269|PubMed:17085506}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankCR9564340.0CR956434.13 M.truncatula DNA sequence from clone MTH2-35N9 on chromosome 3, complete sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_003603161.10.0heat stress transcription factor A-2
SwissprotO809821e-119HSFA2_ARATH; Heat stress transcription factor A-2
SwissprotP411521e-119HSF30_SOLPE; Heat shock factor protein HSF30
TrEMBLA0A2K3MNV60.0A0A2K3MNV6_TRIPR; Heat shock factor protein hsf30-like
STRINGAES734120.0(Medicago truncatula)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF82253143
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G26150.11e-107heat shock transcription factor A2
Publications ? help Back to Top
  1. Liu HC,Charng YY
    Common and distinct functions of Arabidopsis class A1 and A2 heat shock factors in diverse abiotic stress responses and development.
    Plant Physiol., 2013. 163(1): p. 276-90
    [PMID:23832625]
  2. Jung HS, et al.
    Subset of heat-shock transcription factors required for the early response of Arabidopsis to excess light.
    Proc. Natl. Acad. Sci. U.S.A., 2013. 110(35): p. 14474-9
    [PMID:23918368]
  3. Chauhan H,Khurana N,Agarwal P,Khurana JP,Khurana P
    A seed preferential heat shock transcription factor from wheat provides abiotic stress tolerance and yield enhancement in transgenic Arabidopsis under heat stress environment.
    PLoS ONE, 2013. 8(11): p. e79577
    [PMID:24265778]
  4. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  5. Weng M, et al.
    Histone chaperone ASF1 is involved in gene transcription activation in response to heat stress in Arabidopsis thaliana.
    Plant Cell Environ., 2014. 37(9): p. 2128-38
    [PMID:24548003]
  6. Jang YH, et al.
    A homolog of splicing factor SF1 is essential for development and is involved in the alternative splicing of pre-mRNA in Arabidopsis thaliana.
    Plant J., 2014. 78(4): p. 591-603
    [PMID:24580679]
  7. Stief A, et al.
    Arabidopsis miR156 Regulates Tolerance to Recurring Environmental Stress through SPL Transcription Factors.
    Plant Cell, 2014. 26(4): p. 1792-1807
    [PMID:24769482]
  8. Dobrá J, et al.
    The impact of heat stress targeting on the hormonal and transcriptomic response in Arabidopsis.
    Plant Sci., 2015. 231: p. 52-61
    [PMID:25575991]
  9. Yamauchi Y,Kunishima M,Mizutani M,Sugimoto Y
    Reactive short-chain leaf volatiles act as powerful inducers of abiotic stress-related gene expression.
    Sci Rep, 2015. 5: p. 8030
    [PMID:25619826]
  10. Shi H, et al.
    Melatonin induces class A1 heat-shock factors (HSFA1s) and their possible involvement of thermotolerance in Arabidopsis.
    J. Pineal Res., 2015. 58(3): p. 335-42
    [PMID:25711624]
  11. Mueller SP,Krause DM,Mueller MJ,Fekete A
    Accumulation of extra-chloroplastic triacylglycerols in Arabidopsis seedlings during heat acclimation.
    J. Exp. Bot., 2015. 66(15): p. 4517-26
    [PMID:25977236]
  12. Nie S,Yue H,Xing D
    A Potential Role for Mitochondrial Produced Reactive Oxygen Species in Salicylic Acid-Mediated Plant Acquired Thermotolerance.
    Plant Physiol., 2016.
    [PMID:26099269]
  13. Nguyen AH, et al.
    Loss of Arabidopsis 5'-3' Exoribonuclease AtXRN4 Function Enhances Heat Stress Tolerance of Plants Subjected to Severe Heat Stress.
    Plant Cell Physiol., 2015. 56(9): p. 1762-72
    [PMID:26136597]
  14. Hu Z, et al.
    Histone acetyltransferase GCN5 is essential for heat stress-responsive gene activation and thermotolerance in Arabidopsis.
    Plant J., 2015. 84(6): p. 1178-91
    [PMID:26576681]
  15. Lämke J,Brzezinka K,Bäurle I
    HSFA2 orchestrates transcriptional dynamics after heat stress in Arabidopsis thaliana.
    Transcription, 2016. 7(4): p. 111-4
    [PMID:27383578]
  16. Wang X,Huang W,Liu J,Yang Z,Huang B
    Molecular regulation and physiological functions of a novel FaHsfA2c cloned from tall fescue conferring plant tolerance to heat stress.
    Plant Biotechnol. J., 2017. 15(2): p. 237-248
    [PMID:27500592]
  17. Chen ST,He NY,Chen JH,Guo FQ
    Identification of core subunits of photosystem II as action sites of HSP21, which is activated by the GUN5-mediated retrograde pathway in Arabidopsis.
    Plant J., 2017. 89(6): p. 1106-1118
    [PMID:27943531]
  18. Kataoka R,Takahashi M,Suzuki N
    Coordination between bZIP28 and HSFA2 in the regulation of heat response signals in Arabidopsis.
    Plant Signal Behav, 2017. 12(11): p. e1376159
    [PMID:28873003]
  19. Wang X,Zhuang L,Shi Y,Huang B
    Up-Regulation of HSFA2c and HSPs by ABA Contributing to Improved Heat Tolerance in Tall Fescue and Arabidopsis.
    Int J Mol Sci, 2018.
    [PMID:28914758]
  20. Llamas E,Pulido P,Rodriguez-Concepcion M
    Interference with plastome gene expression and Clp protease activity in Arabidopsis triggers a chloroplast unfolded protein response to restore protein homeostasis.
    PLoS Genet., 2017. 13(9): p. e1007022
    [PMID:28937985]
  21. Li X, et al.
    Plastid Translation Elongation Factor Tu Is Prone to Heat-Induced Aggregation Despite Its Critical Role in Plant Heat Tolerance.
    Plant Physiol., 2018. 176(4): p. 3027-3045
    [PMID:29444814]
  22. Scharf KD,Rose S,Thierfelder J,Nover L
    Two cDNAs for tomato heat stress transcription factors.
    Plant Physiol., 1993. 102(4): p. 1355-6
    [PMID:8278556]