PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Tp57577_TGAC_v2_mRNA24371
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Trifolieae; Trifolium
Family E2F/DP
Protein Properties Length: 432aa    MW: 47765.2 Da    PI: 4.6259
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Tp57577_TGAC_v2_mRNA24371genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP82.53.5e-26110175171
                    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                                r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liek+ kn+i wkg
  Tp57577_TGAC_v2_mRNA24371 110 RYDSSLGLLTKKFINLIKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKNIKNRILWKG 175
                                6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.1E-27107177IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.3E-33110175IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467856.44E-17110173IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023192.6E-23112175IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440742.28E-33188292No hitNo description
CDDcd146605.37E-48191292No hitNo description
PfamPF164211.1E-33191290IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 432 aa     Download sequence    Send to blast
LELPTVARRG RLPEHQXXXX XXDHVTEAVI VRSPLIKRKN GMNESQGESQ KSSNSPGYTN  60
VTNSPFKTPL SAKEGRTHKS RVSKEGRSCP QTPISNAGSP SPLTPAGSCR YDSSLGLLTK  120
KFINLIKHAE DGILDLNKAA ETLEVQKRRI YDITNVLEGI GLIEKNIKNR ILWKGIESST  180
PGNVDGDINM LKSEVEKLSL EEQRLDDKIR EMQEKLRSLS EDENNQKFLF VTEEDIKGLP  240
CFQNETLIAI KAPHGTTLEV PDPEEAVDYL QRRYRIILRS TMGPIDVYLI SQFEEKFEEI  300
NAAVAPTSLA IASSSESTEQ QVTEMVPAEC SGNGLDPQAL LSSQTYSDLN VSQDLAGGMM  360
KIVPSDADND ADYWLLSDAE VSITDMWRTD SSVDWSAVDM LHPDFEMIAR PQTPSPVLAE  420
APSTVANPNQ R*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A8e-24105176274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapTp57577_TGAC_v2_mRNA24371
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_003592452.20.0transcription factor E2FA isoform X2
SwissprotQ9FNY01e-151E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A2K3NN000.0A0A2K3NN00_TRIPR; Transcription factor E2FA-like protein
STRINGAES627030.0(Medicago truncatula)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-143E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]