PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_010557436.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Cleomaceae; Tarenaya
Family E2F/DP
Protein Properties Length: 416aa    MW: 45892.3 Da    PI: 4.5767
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_010557436.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP84.21e-26112177171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL+llt+kf++l++++e+g+++ln++a+ L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  XP_010557436.1 112 RYDSSLGLLTKKFIALIQQAEDGVLDLNKAASIL---EV--QKRRIYDITNVLEGVGLIEKKLKNRIQWKG 177
                     6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.5E-28110178IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.09E-16112175IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.3E-34112177IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023195.6E-24114177IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.53E-45188294No hitNo description
SuperFamilySSF1440743.4E-32189294No hitNo description
PfamPF164218.4E-32193292IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 416 aa     Download sequence    Send to blast
MKPPILSPGD LHRFSSASTN QGADREGDSV VAKSTSKRKS DGTDHEAETR DSINVPGYSE  60
AVLTSVQTPL GAKGKAQKTS RSARSKQNGP STPGSNLSSP GGTNNAFGAA CRYDSSLGLL  120
TKKFIALIQQ AEDGVLDLNK AASILEVQKR RIYDITNVLE GVGLIEKKLK NRIQWKGLGV  180
LGPGEAIENV ARLQTELQDL TGEERQLDEQ IRAMQERLRG FSEEEENRKW LFITEEDIKS  240
LPCLQNETLI AIKAPHGTTL EVPDPDEAVD YPLRRYRMVL RSTMGPIDVY LVSQFEEKFE  300
EIHREEAMPK VPSSSVLTAE MENAEEGEQK DQRTRSSADP SRDLSTGITK IIPDDFDADA  360
DYWLLSDASL GVSITELWQI EPDMQWTELG PLCEEYAIPR PESPLFNPKA ATSTSG
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A6e-26108179375PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_010557436.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010557436.10.0PREDICTED: transcription factor E2FB-like isoform X2
SwissprotQ9FV711e-136E2FB_ARATH; Transcription factor E2FB
TrEMBLV4RS351e-172V4RS35_9ROSI; Uncharacterized protein
STRINGXP_010557435.10.0(Tarenaya hassleriana)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.31e-134E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]