PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_010546013.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Cleomaceae; Tarenaya
Family E2F/DP
Protein Properties Length: 392aa    MW: 43937.4 Da    PI: 9.774
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_010546013.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP74.11.4e-232287171
         E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                    rk+ksL+ll+++fl+l+++   ++v l+++a++L    v  +rRRiYDi+NVLe+++++++++kn+++wkg
  XP_010546013.1 22 RKQKSLGLLCTNFLALYNRDGIDMVGLDDAATKL---GV--ERRRIYDIVNVLESVGVLTRRAKNQYTWKG 87
                    79*****************999************...**..****************************98 PP

2E2F_TDP80.41.6e-25157237171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                     r+eksL+lltq+f+kl+ +se++i++l+e+ak L+ +      +++k+RR+YDi+NVL+++nliek     ++k++++w g
  XP_010546013.1 157 RREKSLGLLTQNFVKLFVCSEAQIISLDEAAKLLLGDahntsIMRTKVRRLYDIANVLSSMNLIEKthtseTRKPAFKWLG 237
                     689**************************************999************************9999*******87 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.9E-261888IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.42E-162185IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.8E-282287IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.3E-202387IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.1E-23154238IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.6E-33157237IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.0E-20159237IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.75E-14159238IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 392 aa     Download sequence    Send to blast
MPPTLSTPAL DSSSSRHHSY SRKQKSLGLL CTNFLALYNR DGIDMVGLDD AATKLGVERR  60
RIYDIVNVLE SVGVLTRRAK NQYTWKGFGA IPGALKELKD EGIKDTFHRF YSNENEKVSD  120
DDDDEEDSSQ PYSSSQNDGS KLGSLPNSSA SSKIDNRREK SLGLLTQNFV KLFVCSEAQI  180
ISLDEAAKLL LGDAHNTSIM RTKVRRLYDI ANVLSSMNLI EKTHTSETRK PAFKWLGYSG  240
EPVHVPSNNF KQNETRKRVF GTDLTNVGVK KNKTASFALE NTSEKMLQMS KQTVSKKSSF  300
TKTSKVQESS IYGARSYQFG PFAPASATSH SFALDNNSKS VTELENLVSV HRPCYHNQVL  360
KDLFAHYMEA WKSWYGEVAR KKNPLAKTSQ HH
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A1e-41212293228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_010546013.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010546013.10.0PREDICTED: E2F transcription factor-like E2FE
SwissprotQ8LSZ40.0E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLE4MXF00.0E4MXF0_EUTHA; mRNA, clone: RTFL01-26-N13
TrEMBLV4LPM20.0V4LPM2_EUTSA; Uncharacterized protein
STRINGXP_010546013.10.0(Tarenaya hassleriana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM63042743
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-167DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]