PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_010535712.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Cleomaceae; Tarenaya
Family E2F/DP
Protein Properties Length: 458aa    MW: 50133 Da    PI: 4.2622
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_010535712.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP74.51.1e-23136201171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL++lt+++++l++++e+gi++l+e+a  L   +v  k+RR+YDi+NVLe+++l+ek+ kn+i+wkg
  XP_010535712.1 136 RYNSSLGVLTKNLVNLIKHVEDGILDLREAAAIL---QV--KKRRLYDITNVLEGIGLMEKTVKNKIQWKG 201
                     6789******************************...99..9***************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.2E-24134203IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.9E-29136201IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467855.85E-15136199IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023193.3E-21138201IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146605.18E-42212318No hitNo description
SuperFamilySSF1440744.97E-29214318No hitNo description
PfamPF164211.1E-30217316IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 458 aa     Download sequence    Send to blast
MSESQKPSKS PPPKRQLHPA VFSMRSAAFG DYHRFDATKR GGASDQETEA IVFKSPSQVR  60
QALSLHQHPK PETDTANRTP ESNELSTEEE EEEEEVGKSN DSIHTPVSEE VGKAQNSSDS  120
KKGSPGDNFG QAGTSRYNSS LGVLTKNLVN LIKHVEDGIL DLREAAAILQ VKKRRLYDIT  180
NVLEGIGLME KTVKNKIQWK GLDVSSPEET AESIAKLQEE TQNLTAEETK LDEQIREMQE  240
KISSLSEDEN NKKLLFVTKE DINSIPSFQN ETLIAVSALP GTMLEVPDPD EGGDSTQRRY  300
SICLRSTMGP IDVYLVSEFE ELSSRVMLAG ENGADAALDL PSTSGSHENQ ETATDNNMES  360
QEQGVAQIMC SDNELDDFVN GILNTVPSDW DAGMDYWLLS EADDVSITER WLSEPEVNLN  420
PSSSHDQESA PPGGTTLQQP QPPSSPKAEH SAAKSTGS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-19135202674PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_010535712.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_019057791.10.0PREDICTED: transcription factor E2FB-like
SwissprotQ9FV711e-145E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A1J3DY821e-153A0A1J3DY82_NOCCA; Transcription factor E2FB (Fragment)
TrEMBLA0A1J3K7H51e-153A0A1J3K7H5_NOCCA; Transcription factor E2FB
STRINGXP_010535712.10.0(Tarenaya hassleriana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-140E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]