PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_010527132.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Cleomaceae; Tarenaya
Family E2F/DP
Protein Properties Length: 486aa    MW: 53819.8 Da    PI: 4.6524
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_010527132.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP855.9e-27175240171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL+ lt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  XP_010527132.1 175 RYDSSLGFLTKKFINLIKQAEDGMLDLNKAAEKL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 240
                     6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.8E-29172242IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.72E-17175238IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.8E-34175240IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.6E-24177240IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440748.11E-34253357No hitNo description
CDDcd146604.37E-49253357No hitNo description
PfamPF164212.5E-34256355IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 486 aa     Download sequence    Send to blast
MSDGARSSLF PAPPAPGPPQ PQHPPSSPAP SPKTSAPVMP PIRRHLAFAS TKPPFHPSDE  60
YHRFVPCPAS NTDDNCVVNG FRVADQEEDA IVVRSPALKR KSTMDSGDVQ SNNGFTSPCF  120
TSLSNTPYQT PVSEKRGRVI NRSKASKGNR STPQTPISNA VAASPATLTP TGSCRYDSSL  180
GFLTKKFINL IKQAEDGMLD LNKAAEKLEV QKRRIYDITN VLEGIGLIEK KLKNRIQWKG  240
FDARRPGDMD ADVSVLQAEI ENLTVEEKTL DNQIREMQEK LRDLSENENN QKWLFVTEED  300
IKSLPCFQNE TLIAIKAPHG TTLEVPDPDE AADYPQRRYR IILRSTMGPI DVYLVSQFEE  360
KYEDANGADP QGNLPIASSS GSNENNDIET FTIDNTRSEV QPQVTHAQSS TSDLDSLQDQ  420
VGGMLKITPS DVENDDYWLL SGTELSMTEY WKTDFGIDWD FGTADISTAT PRNETPEIPS  480
VESSRR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-22170240273PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_010527132.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010527132.10.0PREDICTED: transcription factor E2FA-like isoform X1
SwissprotQ9FNY00.0E2FA_ARATH; Transcription factor E2FA
TrEMBLV4MAR90.0V4MAR9_EUTSA; Uncharacterized protein
STRINGXP_010527132.10.0(Tarenaya hassleriana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.10.0E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]