PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_010520690.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Cleomaceae; Tarenaya
Family E2F/DP
Protein Properties Length: 481aa    MW: 52316.1 Da    PI: 4.6018
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_010520690.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP85.63.9e-27168233171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  XP_010520690.1 168 RYDSSLGLLTKKFITLIKQAEDGMLDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 233
                     6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.2E-29165235IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467854.15E-17168231IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.6E-34168233IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.1E-24170233IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146606.23E-49246350No hitNo description
SuperFamilySSF1440741.65E-33247350No hitNo description
PfamPF164212.8E-34249348IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 481 aa     Download sequence    Send to blast
MSGDARSSSL AAPPPSPAPA QYATSSSATS APVVPPIRRN LAFASTKPPF HPPDHYHRFA  60
PSASNTSDSS VVVNGCRIAD QEEDAIVVRS PALKRKPSVD AGDIQSNNGF ISSGFNGISN  120
STCQTPVSAK GGRINNRSKA SKGNRSTPQT PISNAASPAT LTPTGSCRYD SSLGLLTKKF  180
ITLIKQAEDG MLDLNKAAET LEVQKRRIYD ITNVLEGIGL IEKKLKNRIQ WKGVDASRPG  240
DMDANVIVLQ AEIENLTIEE QTLDNQIREM QERLRDLSEN ENNQKWLFVT EEDIKSLPCF  300
QNETLIAIKA PHGTTLEVPD PDEAADYPQR RYRIILRSTM GPIDVYLVSQ FEEKSEDANG  360
ADPQAILPIA SGSGSNENHD METFTIGNTR SEIQPQVAHA QPSTSDLDSL QDQVGGMLKI  420
TPSDVDNDDY WLLSGNELSM TEYWKTDSTA GIDWDFGIAD VSTPRAETPS ITGEIPSTTQ  480
R
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-25163234274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_010520690.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010520690.10.0PREDICTED: transcription factor E2FA isoform X2
SwissprotQ9FNY00.0E2FA_ARATH; Transcription factor E2FA
TrEMBLV4MAR90.0V4MAR9_EUTSA; Uncharacterized protein
STRINGXP_010520690.10.0(Tarenaya hassleriana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.10.0E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]