PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID PGSC0003DMP400045082
Common NameGAME9
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum
Family ERF
Protein Properties Length: 223aa    MW: 24842.8 Da    PI: 6.5552
Description ERF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PGSC0003DMP400045082genomePGSCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP247.54.4e-1585135255
                   AP2   2 gykGVrwdkkrgrWvAeIrdpseng.krkrfslgkfgtaeeAakaaiaarkkleg 55 
                           ++ GVr++  +g + AeIrdp   + + +r +lg++ ++++Aa a+++a+ k++g
  PGSC0003DMP400045082  85 RFIGVRRRQ-WGTFSAEIRDP---NrRGARLWLGTYESPQDAALAYDQAAYKIRG 135
                           578***887.**********9...4334*************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF008475.1E-1085135IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.105.2E-2885144IPR001471AP2/ERF domain
PROSITE profilePS5103221.58885143IPR001471AP2/ERF domain
CDDcd000182.47E-2585145No hitNo description
SMARTSM003802.5E-2785149IPR001471AP2/ERF domain
SuperFamilySSF541716.15E-2086144IPR016177DNA-binding domain
PRINTSPR003674.0E-108697IPR001471AP2/ERF domain
PRINTSPR003674.0E-10125145IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 223 aa     Download sequence    Send to blast
MNIAIDDDEI FSLPSLDELE SITHLLYDDD SDFFETLSPM SLDSTTLLPN NPTPNSLESP  60
VRPEGTKETF VAREHEESAP QDWRRFIGVR RRQWGTFSAE IRDPNRRGAR LWLGTYESPQ  120
DAALAYDQAA YKIRGTKARL NFPDLIGSDV PMPPRVTARR RTRSRSRSPE PSTTSSSSSS  180
SSSSSSSSSM ENGTKKRKID LINSIAKAKL LCGVNLQMLI QM*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1gcc_A4e-2284143160ETHYLENE RESPONSIVE ELEMENT BINDING FACTOR 1
2gcc_A5e-2284148468ATERF1
3gcc_A5e-2284148468ATERF1
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtActs as a transcriptional activator and may be involved in disease resistance pathways. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways mediated by ethylene, that seems to depend on a protein kinase cascade, and to be influenced by methyl-jasmonate. {ECO:0000269|PubMed:10652129, ECO:0000269|PubMed:10792818, ECO:0000269|PubMed:7756828, ECO:0000269|Ref.2}.
Function -- GeneRIF ? help Back to Top
  1. GLYCOALKALOID METABOLISM 9 (GAME9) controls steroid glycoalkaloid biosynthesis and upstream mevalonate pathway genes. [GAME9]
    [PMID: 26876023]
Cis-element ? help Back to Top
SourceLink
PlantRegMapPGSC0003DMP400045082
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by ethephon (ethylene-releasing compound) in buds and to a lower extent in leaves. Strongly induced by cycloheximide and mechanical stimuli. Wounding leads to a both local and systemic expression, independently of ethylene, and through a de-novo-protein-synthesis-independent regulation. Wound induction is reduced by methyl-jasmonate. Induction by purified xylanase from Trichoderma viride (TvX) and another elicitor from Phytophthora infestans (PiE), that appears to be mediated by both protein kinases and protein phosphatases. {ECO:0000269|PubMed:10652129, ECO:0000269|PubMed:12090623, ECO:0000269|PubMed:7756828, ECO:0000269|Ref.2}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankHG9755130.0HG975513.1 Solanum lycopersicum chromosome ch01, complete genome.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006347956.11e-161PREDICTED: ethylene-responsive transcription factor 1-like isoform X2
RefseqXP_015164502.11e-161PREDICTED: ethylene-responsive transcription factor 1-like isoform X1
SwissprotQ404798e-34ERF2_TOBAC; Ethylene-responsive transcription factor 2
TrEMBLM1CGB01e-160M1CGB0_SOLTU; Uncharacterized protein
STRINGPGSC0003DMT4000668461e-161(Solanum tuberosum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA21241165
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G44840.13e-21ethylene-responsive element binding factor 13
Publications ? help Back to Top
  1. Nakano T,Nishiuchi T,Suzuki K,Fujimura T,Shinshi H
    Studies on transcriptional regulation of endogenous genes by ERF2 transcription factor in tobacco cells.
    Plant Cell Physiol., 2006. 47(4): p. 554-8
    [PMID:16452120]
  2. Xu X, et al.
    Genome sequence and analysis of the tuber crop potato.
    Nature, 2011. 475(7355): p. 189-95
    [PMID:21743474]
  3. C
    GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway.
    Nat Commun, 2016. 7: p. 10654
    [PMID:26876023]