PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID PGSC0003DMP400034101
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum
Family E2F/DP
Protein Properties Length: 454aa    MW: 50667.1 Da    PI: 4.853
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PGSC0003DMP400034101genomePGSCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.32.3e-27127192171
               E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                           r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  PGSC0003DMP400034101 127 RYDSSLGLLTKKFINLIKHAEDGMLDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 192
                           6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.5E-29125193IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.9E-34127192IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.9E-17127190IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.7E-24129192IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146603.13E-50203309No hitNo description
SuperFamilySSF1440747.32E-34205309No hitNo description
PfamPF164211.1E-34208307IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 454 aa     Download sequence    Send to blast
MKPQQQQQQQ QSLKRQLQFS SIKPVFGDYH RFSTEPVDCS SQEPPGIVVK TPPLKRKSAA  60
ANYGQGVGDR NPASGYANVN SPIQTPVSGK NAQKVPRTSK ARSASQAVTS NVGSPSGNNV  120
TPVGPCRYDS SLGLLTKKFI NLIKHAEDGM LDLNKAADTL EVQKRRIYDI TNVLEGIGLI  180
EKKLKNRIQW KGQGVSKPGE ADESVASLQA EVEKLTVEEH RLDDQIREMQ ESLRDLSEDE  240
NNQRWLFVTE DDIKSLPCFQ NETLIAIKAP HGTTLEVPDP DEAVDYPQRR YRIVLRSTMG  300
PIDVYLVSQF EEKFEEVNAV EAPPSVPSTS GLNEKATATL ATEENEEVDI GMEGKENQNV  360
RSEVGTSQDF MTGIMKIVPD VDNEADYWLL SDADVSITDM WRTECILLKS VFCYYQKDLT  420
LYILILTLSM YYGRLHVVTF LGNLFCASKL NFY*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A9e-27122194275PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapPGSC0003DMP400034101
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT0128400.0BT012840.1 Lycopersicon esculentum clone 113908F, mRNA sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006362858.10.0PREDICTED: transcription factor E2FB
SwissprotQ9FV711e-141E2FB_ARATH; Transcription factor E2FB
TrEMBLM1BQE90.0M1BQE9_SOLTU; Uncharacterized protein
STRINGPGSC0003DMT4000505120.0(Solanum tuberosum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-138E2F transcription factor 1
Publications ? help Back to Top
  1. Xu X, et al.
    Genome sequence and analysis of the tuber crop potato.
    Nature, 2011. 475(7355): p. 189-95
    [PMID:21743474]
  2. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  3. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  4. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]