PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID PGSC0003DMP400033079
Common NameLOC102601425
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum
Family bHLH
Protein Properties Length: 313aa    MW: 35241.6 Da    PI: 4.4586
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PGSC0003DMP400033079genomePGSCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH30.85.3e-10133176755
                           HHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                   HLH   7 erErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                           + Er+RR r+++++  Lr+l+P+      +K++Ka+i   A+ Y++ Lq
  PGSC0003DMP400033079 133 ISERKRRGRMKEKLYALRSLVPNI-----TKMDKASIIGDAILYVQGLQ 176
                           67*********************7.....7*****************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5088814.869126175IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474593.01E-15128199IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.102.1E-15128195IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000834.45E-11128178No hitNo description
SMARTSM003537.5E-13132181IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.3E-7133176IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0034756Biological Processregulation of iron ion transport
GO:0071281Biological Processcellular response to iron ion
GO:0071369Biological Processcellular response to ethylene stimulus
GO:0071732Biological Processcellular response to nitric oxide
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 313 aa     Download sequence    Send to blast
MESGNASMEN NVNDIGLINF LDEDNFEQFI ELIRGETADP IVKFCPNYDC EHITGCFSAA  60
NAQFEPTSMD FYDTTLPDPI SLYTSFPGEI KLDDDDDDEE EEEDCDESSG TTATTKMTPT  120
TKGTRTDRSR TLISERKRRG RMKEKLYALR SLVPNITKMD KASIIGDAIL YVQGLQTKAK  180
KLKVEIAEFE SSINQSGLFQ NAKKMNFTSY YPAIKRITKM DINQVEEKGF YVRLICNKGR  240
QIAASLFKAL ESLTGFNVQT SNLATSTNDY IFTFTLNVRE CHEVDINFGN LKLWIASAFL  300
NQGFDFETSS LV*
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor. Essential protein involved in iron uptake responses. Regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation. Confers enhanced iron mobilization responses at low iron supply. {ECO:0000269|PubMed:15539473, ECO:0000269|PubMed:15556641, ECO:0000269|PubMed:16117851}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapPGSC0003DMP400033079
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: In roots by iron deficiency. Repressed by cytokinins. Induced by cold, UV, ethylene (ACC), jasmonic acid (JA), flagellin, and salicylic acid (SA) treatments. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:15531708, ECO:0000269|PubMed:15539473, ECO:0000269|PubMed:15556641, ECO:0000269|PubMed:18397377}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF4378780.0AF437878.1 Lycopersicon esculentum bHLH transcriptional regulator (fer) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006338844.10.0PREDICTED: transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR
SwissprotQ0V7X49e-91FIT_ARATH; Transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR
TrEMBLM1BN250.0M1BN25_SOLTU; Uncharacterized protein
STRINGPGSC0003DMT4000489410.0(Solanum tuberosum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA37822340
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G28160.11e-82FER-like regulator of iron uptake
Publications ? help Back to Top
  1. Xu X, et al.
    Genome sequence and analysis of the tuber crop potato.
    Nature, 2011. 475(7355): p. 189-95
    [PMID:21743474]
  2. Schmid NB, et al.
    Feruloyl-CoA 6'-Hydroxylase1-dependent coumarins mediate iron acquisition from alkaline substrates in Arabidopsis.
    Plant Physiol., 2014. 164(1): p. 160-72
    [PMID:24246380]
  3. Doustaly F, et al.
    Uranium perturbs signaling and iron uptake response in Arabidopsis thaliana roots.
    Metallomics, 2014. 6(4): p. 809-21
    [PMID:24549117]
  4. Le CT, et al.
    ZINC FINGER OF ARABIDOPSIS THALIANA12 (ZAT12) Interacts with FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT) Linking Iron Deficiency and Oxidative Stress Responses.
    Plant Physiol., 2016. 170(1): p. 540-57
    [PMID:26556796]
  5. Yang L, et al.
    Carbon Monoxide Interacts with Auxin and Nitric Oxide to Cope with Iron Deficiency in Arabidopsis.
    Front Plant Sci, 2016. 7: p. 112
    [PMID:27014280]
  6. Zhou C, et al.
    Paenibacillus polymyxa BFKC01 enhances plant iron absorption via improved root systems and activated iron acquisition mechanisms.
    Plant Physiol. Biochem., 2016. 105: p. 162-173
    [PMID:27105423]
  7. Mai HJ,Pateyron S,Bauer P
    Iron homeostasis in Arabidopsis thaliana: transcriptomic analyses reveal novel FIT-regulated genes, iron deficiency marker genes and functional gene networks.
    BMC Plant Biol., 2016. 16(1): p. 211
    [PMID:27716045]
  8. Zhou C, et al.
    Exogenous Melatonin Improves Plant Iron Deficiency Tolerance via Increased Accumulation of Polyamine-Mediated Nitric Oxide.
    Int J Mol Sci, 2017.
    [PMID:27792144]
  9. Ezer D, et al.
    The G-Box Transcriptional Regulatory Code in Arabidopsis.
    Plant Physiol., 2017. 175(2): p. 628-640
    [PMID:28864470]
  10. Naranjo-Arcos MA, et al.
    Dissection of iron signaling and iron accumulation by overexpression of subgroup Ib bHLH039 protein.
    Sci Rep, 2017. 7(1): p. 10911
    [PMID:28883478]
  11. Kailasam S,Wang Y,Lo JC,Chang HF,Yeh KC
    S-Nitrosoglutathione works downstream of nitric oxide to mediate iron-deficiency signaling in Arabidopsis.
    Plant J., 2018. 94(1): p. 157-168
    [PMID:29396986]
  12. Cui Y, et al.
    Four IVa bHLH Transcription Factors Are Novel Interactors of FIT and Mediate JA Inhibition of Iron Uptake in Arabidopsis.
    Mol Plant, 2018. 11(9): p. 1166-1183
    [PMID:29960107]