PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID PGSC0003DMP400010520
Common NameLOC102578597
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum
Family E2F/DP
Protein Properties Length: 444aa    MW: 48520.9 Da    PI: 4.3886
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PGSC0003DMP400010520genomePGSCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP85.73.4e-27124189171
               E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                           r+++sL+llt+kf++ll+++++gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn i+wkg
  PGSC0003DMP400010520 124 RYDNSLGLLTKKFINLLKHAKDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNMIQWKG 189
                           689*******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.7E-29122191IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.36E-17124187IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013729.1E-35124189IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.8E-24126189IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146603.79E-45200306No hitNo description
SuperFamilySSF1440741.44E-30202306No hitNo description
PfamPF164211.6E-30205304IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 444 aa     Download sequence    Send to blast
MQPNQQQPSK RQLPFTSSKP PLGDYHRLST DPLQPSSQEP EGIVVKSTPL KRKSGTTNYE  60
QGVGAQVAGS GSFNGSSPMQ TPISGKDGNS QKAPRTSKAR SAAQATSSLG SPSGNNVTPV  120
GPCRYDNSLG LLTKKFINLL KHAKDGILDL NKAADTLEVQ KRRIYDITNV LEGIGLIEKK  180
LKNMIQWKGL DVLRPGEVDE SVTSLQAGVE NLTIEESRLD EQIRKMEERL RDLSGDENNK  240
RWLFVTEDDI KSLPCLQNDT LIAIKAPHGT SLEVPDPDEA VDYPQRRYRI VFRSTMGPID  300
VYLVSKFEEK FEEINTVEEP STMPPTSGFI ENETVTLPVD DGGGVGVGME EQENQRECPD  360
AGTSQDFVSG IVKIVPDVDN EADYWLLSDA DVSITDMWTE SALDWNAFDS INEDYSIADV  420
STPRAQTPPS STTEVPSANT TGS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-27119190274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapPGSC0003DMP400010520
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0253470.0AB025347.1 Nicotiana tabacum mRNA for transcription factor, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006361100.10.0PREDICTED: transcription factor E2FB-like isoform X1
SwissprotQ9FV711e-141E2FB_ARATH; Transcription factor E2FB
TrEMBLM1A5L70.0M1A5L7_SOLTU; Uncharacterized protein
STRINGPGSC0003DMT4000151880.0(Solanum tuberosum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-144E2F transcription factor 1
Publications ? help Back to Top
  1. Xu X, et al.
    Genome sequence and analysis of the tuber crop potato.
    Nature, 2011. 475(7355): p. 189-95
    [PMID:21743474]
  2. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  3. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  4. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]