PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID 136738
Common NameE2F2-2, SELMODRAFT_136738
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Lycopodiidae; Selaginellales; Selaginellaceae; Selaginella
Family E2F/DP
Protein Properties Length: 353aa    MW: 39223.4 Da    PI: 4.5538
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
136738genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.71.7e-2752117171
  E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
              r+++sL+llt+kf++ll+++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
   136738  52 RYDSSLGLLTKKFIDLLKQAEDGVLDLNKAAETL---KV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 117
              6899******************************...88..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.1E-2949118IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.7E-3552117IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023194.8E-2554117IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.47E-1754118IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF1440742.59E-32129233No hitNo description
CDDcd146603.54E-49130233No hitNo description
PfamPF164211.9E-33134232IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 353 aa     Download sequence    Send to blast
SPVVTPGCGP GSKRVSRPKF VKNATKSGPQ TPGSFFAGSP AASVPTPVST CRYDSSLGLL  60
TKKFIDLLKQ AEDGVLDLNK AAETLKVQKR RIYDITNVLE GIGLIEKKLK NRIRWKGLGF  120
TTPMDISPDM TAFKSEVDEL HVEERDLDES IREMREKLKM LSEDENNKQW LYVTEDDIKS  180
LPCFRNETLI AIKAPHGTTL EVPDPDEAVE YPQRRYQILL RSTMGPIDVY LVSRFEEKFE  240
ETNTLELTGP SRTVEENTIA VIENVEHVVT RPPPSHFAGA ESSSMPDYGN GIMKILPAEV  300
DTDADYWLLS DAGVSITDMW RTDPSTAMWD EVQLQAAEFG IEGEPQTPPM AS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-2647119275PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
18490LKVQKRR
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024522748.10.0transcription factor E2FA
SwissprotQ9FNY01e-108E2FA_ARATH; Transcription factor E2FA
TrEMBLD8TCC40.0D8TCC4_SELML; Uncharacterized protein E2F2-2 (Fragment)
STRINGEFJ056920.0(Selaginella moellendorffii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP12251749
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-112E2F transcription factor 3
Publications ? help Back to Top
  1. Banks JA, et al.
    The Selaginella genome identifies genetic changes associated with the evolution of vascular plants.
    Science, 2011. 332(6032): p. 960-3
    [PMID:21551031]
  2. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]