PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID 118926
Common NameE2F1-1, SELMODRAFT_445661
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Lycopodiidae; Selaginellales; Selaginellaceae; Selaginella
Family E2F/DP
Protein Properties Length: 176aa    MW: 19884.6 Da    PI: 4.608
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
118926genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP76.72.3e-24158971
  E2F_TDP  9 ltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
             lt+kf++l+ ++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
   118926  1 LTKKFINLIDQAEDGVLDLNNAADTL---HV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 58
             79************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF467854.9E-15156IPR011991Winged helix-turn-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.1E-24159IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023199.3E-22158IPR003316E2F/DP family, winged-helix DNA-binding domain
SMARTSM013725.2E-24158IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146609.91E-4772174No hitNo description
SuperFamilySSF1440741.7E-3173174No hitNo description
PfamPF164211.7E-3275174IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 176 aa     Download sequence    Send to blast
LTKKFINLID QAEDGVLDLN NAADTLHVQK RRIYDITNVL EGIGLIEKKL KNRIRWKGLG  60
LSVADSDSTG LLSSLQSEVD DLHAQEESLD EKIRAMREKL KTMCEDVSNQ QWLYVTEDDI  120
KGLPCFQNET LIAIKAPQGT TLEVPDPDEA VEYPQRRYQI LLRSAFGPID VYLVR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-231601575PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024518617.11e-124transcription factor E2FA isoform X1
SwissprotQ9FV716e-76E2FB_ARATH; Transcription factor E2FB
TrEMBLD8SK881e-122D8SK88_SELML; Uncharacterized protein E2F1-1
TrEMBLD8T0B31e-123D8T0B3_SELML; Uncharacterized protein E2F1-2
STRINGEFJ098771e-123(Selaginella moellendorffii)
STRINGEFJ151851e-123(Selaginella moellendorffii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP12251749
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.32e-78E2F transcription factor 1
Publications ? help Back to Top
  1. Banks JA, et al.
    The Selaginella genome identifies genetic changes associated with the evolution of vascular plants.
    Science, 2011. 332(6032): p. 960-3
    [PMID:21551031]
  2. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  3. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  4. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]