PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID SMil_00016833-RA_Salv
Common NameWRI12
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia
Family AP2
Protein Properties Length: 608aa    MW: 66928.3 Da    PI: 8.2506
Description AP2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
SMil_00016833-RA_SalvgenomeNDCTCMView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP237.27.4e-12258314155
                    AP2   1 sgykGVrwdkkrgrWvAeIrd.pse.ng.krkrfslgkfgtaeeAakaaiaarkkleg 55 
                            s+y+GV++++++gr++A+++d  ++  g  rk  + g ++ +++Aa+a++ a++k++g
  SMil_00016833-RA_Salv 258 SQYRGVTRHRWTGRYEAHLWDnSCKkEGqTRKGRQ-GGYDMEDKAARAYDLAALKYWG 314
                            78*******************77776664346655.77***99*************98 PP

2AP222.43e-07357391138
                    AP2   1 sgykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgt 38 
                            s y+GV+++++ grW A+I  +     +k  +lg+f  
  SMil_00016833-RA_Salv 357 SIYRGVTRHHQHGRWQARIGRVAG---NKDLYLGTFSK 391
                            57****************988532...5*******965 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000181.43E-16258321No hitNo description
SuperFamilySSF541713.07E-13258323IPR016177DNA-binding domain
PfamPF008473.2E-9258314IPR001471AP2/ERF domain
SMARTSM003808.2E-20259328IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.106.6E-11259322IPR001471AP2/ERF domain
PROSITE profilePS5103216.436259322IPR001471AP2/ERF domain
SuperFamilySSF541711.7E-5357391IPR016177DNA-binding domain
SMARTSM003800.0016358423IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.101.9E-4358391IPR001471AP2/ERF domain
PROSITE profilePS510328.86358390IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 608 aa     Download sequence    Send to blast
MKSMNDEESA TTAADINNWL GFSLSPHMKM EANFSQAPPT SSAAAAPPNN FYLANSAAMF  60
AGDDFHPPLS VMPLKSDGSL CIMEALSRSH SHAPPNSSPK LEDFLGGATM AAAHQAMGLT  120
LDTSFYSQQQ NQNHYFSNYN FYQNEQHQIP QISEDEIPCL KTWMDHHHAL QQHHINNNNS  180
MAEDRSAAAM RSTEIQSLSL SMSPGSQSSC VTASRQISPT QTTECAAMET KKRGAQKLGQ  240
QKQTVHRKSI DTFGQRTSQY RGVTRHRWTG RYEAHLWDNS CKKEGQTRKG RQGGYDMEDK  300
AARAYDLAAL KYWGPSTHIN FGLENYHQEL EDMKNMSRQE YVAHLRRKSS GFSRGASIYR  360
GVTRHHQHGR WQARIGRVAG NKDLYLGTFS KHAGGGGRGL RHCCDQVPGR ERCHQLRHLP  420
YDVEKIMASN TLPTGEVARR TKEGRPAAEA SVEECHASSQ RGEACSSAQV EHVSNGCDWK  480
MVLHNNEAPA PAPGHQGVGS LDVKTLNLGN YQHPTFSVGL HDLMGLDSSQ SQRVVDGSAA  540
TMAPHFSNAS SLVTSLSSSR EASPDRYGGP NKFMSPSSNV GAWIPTAQLR PVPLTTAHLP  600
VFAAWNDA
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that recognizes and binds to the DNA consensus sequence 5'-CAC[AG]N[AT]TNCCNANG-3'. Required for the initiation and growth of ovules integumenta, and for the development of female gametophyte. Plays a critical role in the development of gynoecium marginal tissues (e.g. stigma, style and septa), and in the fusion of carpels and of medial ridges leading to ovule primordia. Also involved in organs initiation and development, including floral organs. Maintains the meristematic competence of cells and consequently sustains expression of cell cycle regulators during organogenesis, thus controlling the final size of each organ by controlling their cell number. Regulates INO autoinduction and expression pattern. As ANT promotes petal cell identity and mediates down-regulation of AG in flower whorl 2, it functions as a class A homeotic gene. {ECO:0000269|PubMed:10528263, ECO:0000269|PubMed:10639184, ECO:0000269|PubMed:10948255, ECO:0000269|PubMed:11041883, ECO:0000269|PubMed:12183381, ECO:0000269|PubMed:12271029, ECO:0000269|PubMed:12655002, ECO:0000269|PubMed:8742706, ECO:0000269|PubMed:8742707, ECO:0000269|PubMed:9001406, ECO:0000269|PubMed:9093862, ECO:0000269|PubMed:9118807}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKJ7844630.0KJ784463.1 Salvia miltiorrhiza AP12/EREBP Transcription Factors (WRI12) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011074331.10.0AP2-like ethylene-responsive transcription factor ANT
SwissprotQ389141e-127ANT_ARATH; AP2-like ethylene-responsive transcription factor ANT
TrEMBLA0A0G2SJF00.0A0A0G2SJF0_SALMI; AP12/EREBP Transcription Factors
STRINGEOY156530.0(Theobroma cacao)
STRINGPOPTR_0002s11550.10.0(Populus trichocarpa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA20742460
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G37750.11e-118AP2 family protein
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Horstman A,Willemsen V,Boutilier K,Heidstra R
    AINTEGUMENTA-LIKE proteins: hubs in a plethora of networks.
    Trends Plant Sci., 2014. 19(3): p. 146-57
    [PMID:24280109]
  3. Li C, et al.
    Ectopic expression of a maize hybrid down-regulated gene ZmARF25 decreases organ size by affecting cellular proliferation in Arabidopsis.
    PLoS ONE, 2014. 9(4): p. e94830
    [PMID:24756087]
  4. Wynn AN,Seaman AA,Jones AL,Franks RG
    Novel functional roles for PERIANTHIA and SEUSS during floral organ identity specification, floral meristem termination, and gynoecial development.
    Front Plant Sci, 2014. 5: p. 130
    [PMID:24778638]
  5. Randall RS, et al.
    AINTEGUMENTA and the D-type cyclin CYCD3;1 regulate root secondary growth and respond to cytokinins.
    Biol Open, 2015. 4(10): p. 1229-36
    [PMID:26340943]
  6. Meng LS,Wang ZB,Yao SQ,Liu A
    The ARF2-ANT-COR15A gene cascade regulates ABA-signaling-mediated resistance of large seeds to drought in Arabidopsis.
    J. Cell. Sci., 2015. 128(21): p. 3922-32
    [PMID:26395398]
  7. Yamaguchi N,Jeong CW,Nole-Wilson S,Krizek BA,Wagner D
    AINTEGUMENTA and AINTEGUMENTA-LIKE6/PLETHORA3 Induce LEAFY Expression in Response to Auxin to Promote the Onset of Flower Formation in Arabidopsis.
    Plant Physiol., 2016. 170(1): p. 283-93
    [PMID:26537561]
  8. Krizek BA, et al.
    RNA-Seq Links the Transcription Factors AINTEGUMENTA and AINTEGUMENTA-LIKE6 to Cell Wall Remodeling and Plant Defense Pathways.
    Plant Physiol., 2016. 171(3): p. 2069-84
    [PMID:27208279]
  9. Han H,Krizek BA
    AINTEGUMENTA-LIKE6 can functionally replace AINTEGUMENTA but alters Arabidopsis flower development when misexpressed at high levels.
    Plant Mol. Biol., 2016. 92(4-5): p. 597-612
    [PMID:27605095]
  10. Karpinska B,Alomrani SO,Foyer CH
    Inhibitor-induced oxidation of the nucleus and cytosol in Arabidopsis thaliana: implications for organelle to nucleus retrograde signalling.
    Philos. Trans. R. Soc. Lond., B, Biol. Sci., 2018.
    [PMID:28808105]
  11. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]