PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID SMil_00004720-RA_Salv
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia
Family E2F/DP
Protein Properties Length: 395aa    MW: 44521.1 Da    PI: 4.3851
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
SMil_00004720-RA_SalvgenomeNDCTCMView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP80.91.1e-2572137171
                E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                            r+++sL llt+kf++l+++se gi++ln++a++L   +v  ++RRiYDi+NVLe+++liek+ kn i+wkg
  SMil_00004720-RA_Salv  72 RYDSSLALLTKKFINLIKHSEGGILELNKAAETL---EV--QKRRIYDITNVLEGIGLIEKTLKNIIQWKG 137
                            6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.7E-2770138IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467857.75E-1772135IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013728.8E-3372137IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023198.8E-2374137IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146608.96E-43150254No hitNo description
SuperFamilySSF1440743.4E-31150254No hitNo description
PfamPF164216.4E-32154252IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 395 aa     Download sequence    Send to blast
MADYGTISVE QNVSPATSAF MNSPHRTPVS VKSEKPQKVP KSTKANRVSC QSLMTNTGSP  60
TGDNLTPVGS CRYDSSLALL TKKFINLIKH SEGGILELNK AAETLEVQKR RIYDITNVLE  120
GIGLIEKTLK NIIQWKGTDV RRPGEVDETL PDIQEEIQNL NSEECRLDER IREMQEKLRG  180
LSEEEDNQRW LFITEEDVKN LPCFENETLI AIKAPHGTTL EVPEPDEAGD YPQRRYKIVL  240
RSTMGPIDVY LVSQFEEINA YEAQPSNLDT SVANETPKEE ITRDEIIAQG EGVQRMCLET  300
SSSHDFVSGI MKIVPDADSD ADYYLLSETD VSITDMWRTE DEVDWDTLNT LHEGYPVSII  360
SPSRDQAPRP KIRDCVQLLR MDGHCIVSSI IIMEI
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-2067137273PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011090314.11e-177transcription factor E2FB isoform X1
RefseqXP_020552667.11e-178transcription factor E2FB isoform X2
SwissprotQ9FV711e-124E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A4D9A2480.0A0A4D9A248_SALSN; Uncharacterized protein
STRINGXP_004140164.11e-161(Cucumis sativus)
STRINGMigut.N02463.1.p1e-161(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-127E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]