PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Sme2.5_00341.1_g00013.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum
Family bHLH
Protein Properties Length: 264aa    MW: 30752.1 Da    PI: 7.019
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Sme2.5_00341.1_g00013.1genomeEGDView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH45.31.5e-1465116155
                              CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                      HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                              +r++h e+Er+RR+++N+ ++ Lr+l+P++   + ++ + a+i+  A+e++k+L+
  Sme2.5_00341.1_g00013.1  65 QRMTHIEVERNRRKQMNQHLHVLRSLMPTS---YVQRGDQASIVGGAIEFVKELE 116
                              79****************************...9******************995 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000831.75E-1263120No hitNo description
Gene3DG3DSA:4.10.280.109.1E-1463119IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474599.81E-1764130IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088815.2564115IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000106.9E-1265116IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003534.1E-1070121IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 264 aa     Download sequence    Send to blast
MFPTIVNDDN YHSFEDVSYC HNYQEEEEEG LMVKEEEING KANEKKKKRK RRIIRMKSSE  60
EVEKQRMTHI EVERNRRKQM NQHLHVLRSL MPTSYVQRGD QASIVGGAIE FVKELEQLLQ  120
CLESQKRRKL YGDQDSLSLM EIQNPQLLFP PNNNFPLSNE NEIGIQEEKA EIKSCLAHVE  180
VKIIGIDNAM IKILSKRRPG QLINTISALQ HLQLNIIHTN VTTIEQNVLY YFNVKIYGET  240
RVSADNIANL VQQIFSFFHA NSPI
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
14449KKKKRK
24551KKKRKRR
34651KKRKRR
46576RMTHIEVERNRR
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankHG9754489e-80HG975448.1 Solanum pennellii chromosome ch09, complete genome.
GenBankHG9755219e-80HG975521.1 Solanum lycopersicum chromosome ch09, complete genome.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016555209.11e-132PREDICTED: transcription factor FAMA-like
SwissprotQ56YJ89e-87FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A2G3CRH71e-131A0A2G3CRH7_CAPCH; Transcription factor FAMA
STRINGPGSC0003DMT4000762231e-128(Solanum tuberosum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA46572341
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.19e-74bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]