PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Solyc01g007760.2.1
Common NameLOC101259362
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum; Lycopersicon
Family E2F/DP
Protein Properties Length: 480aa    MW: 52584.5 Da    PI: 4.7313
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Solyc01g007760.2.1genomeITAGView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.32.3e-27156221171
             E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                         r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Solyc01g007760.2.1 156 RYDSSLGLLTKKFINLIKHAEDGMLDLNQAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 221
                         6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.4E-29154223IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.54E-17156219IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.6E-34156221IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.4E-24158221IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146608.65E-48232338No hitNo description
SuperFamilySSF1440743.14E-33235338No hitNo description
PfamPF164212.7E-33237336IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 480 aa     Download sequence    Send to blast
MTGSSASTGG AAPPTAQSSS AVVNGGGRSQ ISHPIKRYLP FASMRPPFVT PEDYHRFSIP  60
GVDSRIGSAS LQPEAIVVKS PALKRKTGYI KEVESSDWTA NSGYADVANS PLGTPVSGKG  120
GRAHGRSRAT KNNKSGPQTP VYNAGSPSPL TPASCRYDSS LGLLTKKFIN LIKHAEDGML  180
DLNQAADTLE VQKRRIYDIT NVLEGIGLIE KKLKNRIQWK GVESSRPGEV DNDASILKAE  240
TDRLSVEERR LDERIREMQE KLRDMSEDEN NQRWLFVTEE DIKSLPCFQN ETLIAVKAPH  300
GTTLEVPDPD EAVDYPQRRY RIILRSTMGP IDVYLVSQFE EKFEEMNGVE PPTTIPVASS  360
SGSKDYPTME ISTVSNSVTE NEGQTHNVDQ LSSDLGTSQE YNGGMMKILP SDVDNDSDYW  420
LLSDANVSIT DMWKTDSTVE WDGETLLHDF GIDDLGTPRA HTPPSTNADV PDPMNVPPR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A5e-26149222274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC2397381e-134Solanum lycopersicum strain Heinz 1706 chromosome 1 clone hba-240p19 map 1, complete sequence
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_004228901.10.0transcription factor E2FA isoform X2
SwissprotQ9FNY01e-165E2FA_ARATH; Transcription factor E2FA
TrEMBLK4ASX40.0K4ASX4_SOLLC; Uncharacterized protein
STRINGSolyc01g007760.2.10.0(Solanum lycopersicum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Representative plantOGRP12251749
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-168E2F transcription factor 3
Publications ? help Back to Top
  1. Wang Y,van der Hoeven RS,Nielsen R,Mueller LA,Tanksley SD
    Characteristics of the tomato nuclear genome as determined by sequencing undermethylated EcoRI digested fragments.
    Theor. Appl. Genet., 2005. 112(1): p. 72-84
    [PMID:16208505]
  2. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]