PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID 676756222
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Sisymbrieae; Sisymbrium
Family bHLH
Protein Properties Length: 243aa    MW: 27192.8 Da    PI: 6.3529
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
676756222genomeVEGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH51.81.5e-1663115155
                CHHHHHHHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHHH CS
        HLH   1 rrrahnerErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksLq 55 
                ++ +hn+ Er RR++iN  f+ Lr++lP  +   +skKls ++++ +A +YI  Lq
  676756222  63 KKLNHNASERDRRKKINAMFSSLRSCLPAtD---QSKKLSVSATVSQALKYIPVLQ 115
                6789*************************77...******************8887 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000831.79E-1461119No hitNo description
PROSITE profilePS5088814.49462114IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474591.7E-1763132IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000104.3E-1463115IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.102.4E-1563131IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003534.6E-1368120IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009414Biological Processresponse to water deprivation
GO:0010106Biological Processcellular response to iron ion starvation
GO:0055072Biological Processiron ion homeostasis
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 243 aa     Download sequence    Send to blast
MCALVPPLFP NFGWPCGDQS FHVNDDLTDT FLDFPLPDLE VAHQNVSSER HRIFELENPV  60
VMKKLNHNAS ERDRRKKINA MFSSLRSCLP ATDQSKKLSV SATVSQALKY IPVLQEEVKK  120
LIKKKDELSF QISGQKDLLY TDQNGNADKG ATSYASTVYA TRLSETEVMV QISSLKTENC  180
SFANVLSGIE EDGLVLVDAS SSRSQGGRLF YTLHLQINNC NLNSEALNDR LLYLYEKCGK  240
SCT
Functional Description ? help Back to Top
Source Description
UniProtPlays a role in metal homeostasis. Confers tolerance to high zinc (Zn) and nickel (Ni). {ECO:0000269|PubMed:18088336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMap676756222
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up regulated by iron deficiency in roots and leaves, as well as by nickel, high zinc or high copper treatments. Repressed by heat treatment, high iron, low copper and low zinc treatments. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:17516080, ECO:0000269|PubMed:18088336}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009142733.11e-149PREDICTED: transcription factor bHLH100-like
SwissprotQ9ZVB51e-133BH100_ARATH; Transcription factor bHLH100
TrEMBLM4CK751e-148M4CK75_BRARP; Uncharacterized protein
STRINGBra004609.1-P1e-148(Brassica rapa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM48228153
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G41240.11e-122basic helix-loop-helix protein 100
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Maurer F,Naranjo Arcos MA,Bauer P
    Responses of a triple mutant defective in three iron deficiency-induced Basic Helix-Loop-Helix genes of the subgroup Ib(2) to iron deficiency and salicylic acid.
    PLoS ONE, 2014. 9(6): p. e99234
    [PMID:24919188]
  3. Martínez-Trujillo M, et al.
    Chromate alters root system architecture and activates expression of genes involved in iron homeostasis and signaling in Arabidopsis thaliana.
    Plant Mol. Biol., 2014. 86(1-2): p. 35-50
    [PMID:24928490]
  4. Van Dingenen J, et al.
    Strobilurins as growth-promoting compounds: how Stroby regulates Arabidopsis leaf growth.
    Plant Cell Environ., 2017. 40(9): p. 1748-1760
    [PMID:28444690]
  5. Wang C,Yao X,Yu D,Liang G
    Fe-deficiency-induced expression of bHLH104 enhances Fe-deficiency tolerance of Arabidopsis thaliana.
    Planta, 2017. 246(3): p. 421-431
    [PMID:28451750]
  6. Ezer D, et al.
    The G-Box Transcriptional Regulatory Code in Arabidopsis.
    Plant Physiol., 2017. 175(2): p. 628-640
    [PMID:28864470]
  7. Kailasam S,Wang Y,Lo JC,Chang HF,Yeh KC
    S-Nitrosoglutathione works downstream of nitric oxide to mediate iron-deficiency signaling in Arabidopsis.
    Plant J., 2018. 94(1): p. 157-168
    [PMID:29396986]
  8. Kurt F,Filiz E
    Genome-wide and comparative analysis of bHLH38, bHLH39, bHLH100 and bHLH101 genes in Arabidopsis, tomato, rice, soybean and maize: insights into iron (Fe) homeostasis.
    Biometals, 2018. 31(4): p. 489-504
    [PMID:29546482]