PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Rsa1.0_06196.1_g00001.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Raphanus
Family bHLH
Protein Properties Length: 498aa    MW: 57277.9 Da    PI: 5.417
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Rsa1.0_06196.1_g00001.1genomeRGDView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH42.21.4e-13341386454
                              HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
                      HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                              +h  +ErrRR+++N++f +Lr+l+P       +K++K++iL  +++Y+++L
  Rsa1.0_06196.1_g00001.1 341 NHVVAERRRREKLNERFITLRSLVPFV-----TKMDKVSILGDTIDYVNHL 386
                              6999**********************8.....8****************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142154.3E-2921163IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088817.396337386IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000832.60E-13340386No hitNo description
SuperFamilySSF474592.22E-18340403IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.107.8E-19341405IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000105.4E-11341386IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003539.4E-17343392IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010026Biological Processtrichome differentiation
GO:0010214Biological Processseed coat development
GO:2000029Biological Processregulation of proanthocyanidin biosynthetic process
GO:0000976Molecular Functiontranscription regulatory region sequence-specific DNA binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 498 aa     Download sequence    Send to blast
MDESSIIPVW KVTGAEEKEI QGLLKAVVQS VGWTYSLFWQ LCPQRRKLVW SSGFYNGAIK  60
TRKTTQPAEI TAEEAALERS QQLMELYQTL FAGESSMEAR ACTALSPEDL TDTEWFYVLC  120
LTYSFEPPSG MPGKAYARRK QVWMSGVNEV DSKIFSRAIS AKVKENEEFV EHIKSFFQNH  180
PKSNTKPALF EHSINEEHEE DEEVEEMTMS EEIRLGSPDD DDVSNQNLLS DFHIEAPNSL  240
DTQMDMMNLM EEGGSYSQTV STLLMSQLPN LLSDSVSTSS YVQSSFVSWR VENVKEHQQY  300
QREEKASSSS SSQWMLKHMI LRVPLLHENT KNKRVPREEL NHVVAERRRR EKLNERFITL  360
RSLVPFVTKM DKVSILGDTI DYVNHLCKRI HELESTHHEP NQKRMRIGKG RTWEEVEVSI  420
IESDVLLEMR CEYRDGLLLN ILQVLKELGI ETTAVHTAVN DHDFEAEIRA KVRGKKPTIA  480
EVKIAIHQII YLKINSSS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5gnj_A9e-16337395362Transcription factor MYC2
5gnj_B9e-16337395362Transcription factor MYC2
5gnj_E9e-16337395362Transcription factor MYC2
5gnj_F9e-16337395362Transcription factor MYC2
5gnj_G9e-16337395362Transcription factor MYC2
5gnj_I9e-16337395362Transcription factor MYC2
5gnj_M9e-16337395362Transcription factor MYC2
5gnj_N9e-16337395362Transcription factor MYC2
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1345350ERRRRE
2346351RRRREK
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator, when associated with MYB75/PAP1 or MYB90/PAP2. Involved in the control of flavonoid pigmentation. Plays a key role in regulating leucoanthocyanidin reductase (BANYULS) and dihydroflavonol-4-reductase (DFR). Not required for leucoanthocyanidin dioxygenase (LDOX) expression. {ECO:0000269|PubMed:15361138}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapRsa1.0_06196.1_g00001.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankEU1920270.0EU192027.1 Brassica napus bHLH DNA-binding domain transcription factor (TT8.1) mRNA, complete cds.
GenBankKM4034520.0KM403452.1 Brassica rapa cultivar Zi He bHLH transcription factor (TT8) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_018466648.10.0PREDICTED: transcription factor TT8-like
SwissprotQ9FT810.0TT8_ARATH; Transcription factor TT8
TrEMBLA0A218N0C00.0A0A218N0C0_RAPSA; TT8
STRINGBra037887.1-P0.0(Brassica rapa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM94222836
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G09820.10.0bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Kim K,Jiang K,Teng SL,Feldman LJ,Huang H
    Using biologically interrelated experiments to identify pathway genes in Arabidopsis.
    Bioinformatics, 2012. 28(6): p. 815-22
    [PMID:22271267]
  3. Liu Z,Shi MZ,Xie DY
    Regulation of anthocyanin biosynthesis in Arabidopsis thaliana red pap1-D cells metabolically programmed by auxins.
    Planta, 2014. 239(4): p. 765-81
    [PMID:24370633]
  4. Ranocha P,Francoz E,Burlat V,Dunand C
    Expression of PRX36, PMEI6 and SBT1.7 is controlled by complex transcription factor regulatory networks for proper seed coat mucilage extrusion.
    Plant Signal Behav, 2014. 9(11): p. e977734
    [PMID:25531128]
  5. Zhu Z, et al.
    Characterization of the cis elements in the proximal promoter regions of the anthocyanin pathway genes reveals a common regulatory logic that governs pathway regulation.
    J. Exp. Bot., 2015. 66(13): p. 3775-89
    [PMID:25911741]
  6. Zhu Q, et al.
    Ectopic Expression of the Coleus R2R3 MYB-Type Proanthocyanidin Regulator Gene SsMYB3 Alters the Flower Color in Transgenic Tobacco.
    PLoS ONE, 2015. 10(10): p. e0139392
    [PMID:26448466]
  7. Li P, et al.
    Regulation of anthocyanin and proanthocyanidin biosynthesis by Medicago truncatula bHLH transcription factor MtTT8.
    New Phytol., 2016. 210(3): p. 905-21
    [PMID:26725247]
  8. Bulgakov VP,Veremeichik GN,Grigorchuk VP,Rybin VG,Shkryl YN
    The rolB gene activates secondary metabolism in Arabidopsis calli via selective activation of genes encoding MYB and bHLH transcription factors.
    Plant Physiol. Biochem., 2016. 102: p. 70-9
    [PMID:26913794]
  9. Petridis A,Döll S,Nichelmann L,Bilger W,Mock HP
    Arabidopsis thaliana G2-LIKE FLAVONOID REGULATOR and BRASSINOSTEROID ENHANCED EXPRESSION1 are low-temperature regulators of flavonoid accumulation.
    New Phytol., 2016. 211(3): p. 912-25
    [PMID:27125220]
  10. Rai A, et al.
    Coordinate Regulation of Metabolite Glycosylation and Stress Hormone Biosynthesis by TT8 in Arabidopsis.
    Plant Physiol., 2016. 171(4): p. 2499-515
    [PMID:27432888]
  11. Li Y, et al.
    Two IIIf Clade-bHLHs from Freesia hybrida Play Divergent Roles in Flavonoid Biosynthesis and Trichome Formation when Ectopically Expressed in Arabidopsis.
    Sci Rep, 2016. 6: p. 30514
    [PMID:27465838]
  12. Mahmood K,Xu Z,El-Kereamy A,Casaretto JA,Rothstein SJ
    The Arabidopsis Transcription Factor ANAC032 Represses Anthocyanin Biosynthesis in Response to High Sucrose and Oxidative and Abiotic Stresses.
    Front Plant Sci, 2016. 7: p. 1548
    [PMID:27790239]
  13. Zou B, et al.
    Calmodulin-binding protein CBP60g functions as a negative regulator in Arabidopsis anthocyanin accumulation.
    PLoS ONE, 2017. 12(3): p. e0173129
    [PMID:28253311]
  14. Chen K,Liu H,Lou Q,Liu Y
    Ectopic Expression of the Grape Hyacinth (Muscari armeniacum) R2R3-MYB Transcription Factor Gene, MaAN2, Induces Anthocyanin Accumulation in Tobacco.
    Front Plant Sci, 2017. 8: p. 965
    [PMID:28642775]
  15. Kataya ARA, et al.
    PLATINUM SENSITIVE 2 LIKE impacts growth, root morphology, seed set, and stress responses.
    PLoS ONE, 2017. 12(7): p. e0180478
    [PMID:28678890]
  16. Ezer D, et al.
    The G-Box Transcriptional Regulatory Code in Arabidopsis.
    Plant Physiol., 2017. 175(2): p. 628-640
    [PMID:28864470]
  17. Feng K, et al.
    An R2R3-MYB transcription factor, OjMYB1, functions in anthocyanin biosynthesis in Oenanthe javanica.
    Planta, 2018. 247(2): p. 301-315
    [PMID:28965159]
  18. Wen J, et al.
    The C-terminal domains of Arabidopsis GL3/EGL3/TT8 interact with JAZ proteins and mediate dimeric interactions.
    Plant Signal Behav, 2018. 13(1): p. e1422460
    [PMID:29293407]