PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Rsa1.0_02784.1_g00001.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Raphanus
Family bHLH
Protein Properties Length: 227aa    MW: 25117.7 Da    PI: 4.8745
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Rsa1.0_02784.1_g00001.1genomeRGDView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH20.77.4e-0751861555
                             HHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                      HLH 15 riNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55
                             r+++++  Lr+l+P+      +K++Ka+i+  Av Y++ Lq
  Rsa1.0_02784.1_g00001.1 51 RMKDKLYALRSLVPNI-----TKMDKASIVGDAVAYVQGLQ 86
                             799************7.....7*****************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5088810.8233685IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.8E-44291IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000839.93E-85188No hitNo description
SuperFamilySSF474592.88E-1051102IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.2E-45186IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.102.5E-1051104IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 227 aa     Download sequence    Send to blast
MKGRVIALTN LNDLELHNFL VDPNFDQFIN LIRGDDQTIE NPPLDFDLGG RMKDKLYALR  60
SLVPNITKMD KASIVGDAVA YVQGLQSQAK TLKADIAGLE ASLTSTGGYQ EPASVAQKSQ  120
SFRSINPPVS KKIIQMDVIQ VEEKEFYVRL VCNKGEGVAA SLYKSLESLT SFQVQNSNLS  180
SPSPETYLLT YTLDGTCFEQ SLNLPNLKLW ITGSLLNQGF EFIKPFT
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor. Essential protein involved in iron uptake responses. Regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation. Confers enhanced iron mobilization responses at low iron supply. {ECO:0000269|PubMed:15539473, ECO:0000269|PubMed:15556641, ECO:0000269|PubMed:16117851}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapRsa1.0_02784.1_g00001.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: In roots by iron deficiency. Repressed by cytokinins. Induced by cold, UV, ethylene (ACC), jasmonic acid (JA), flagellin, and salicylic acid (SA) treatments. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:15531708, ECO:0000269|PubMed:15539473, ECO:0000269|PubMed:15556641, ECO:0000269|PubMed:18397377}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT0264461e-161BT026446.1 Arabidopsis thaliana At2g28160 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_013634470.11e-118PREDICTED: transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR isoform X1
SwissprotQ0V7X41e-112FIT_ARATH; Transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR
TrEMBLA0A0D3BU901e-117A0A0D3BU90_BRAOL; Uncharacterized protein
TrEMBLA0A3P6CI171e-117A0A3P6CI17_BRAOL; Uncharacterized protein
STRINGBo4g071850.11e-118(Brassica oleracea)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM41872857
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G28160.11e-114FER-like regulator of iron uptake
Publications ? help Back to Top
  1. Schmid NB, et al.
    Feruloyl-CoA 6'-Hydroxylase1-dependent coumarins mediate iron acquisition from alkaline substrates in Arabidopsis.
    Plant Physiol., 2014. 164(1): p. 160-72
    [PMID:24246380]
  2. Doustaly F, et al.
    Uranium perturbs signaling and iron uptake response in Arabidopsis thaliana roots.
    Metallomics, 2014. 6(4): p. 809-21
    [PMID:24549117]
  3. Le CT, et al.
    ZINC FINGER OF ARABIDOPSIS THALIANA12 (ZAT12) Interacts with FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT) Linking Iron Deficiency and Oxidative Stress Responses.
    Plant Physiol., 2016. 170(1): p. 540-57
    [PMID:26556796]
  4. Yang L, et al.
    Carbon Monoxide Interacts with Auxin and Nitric Oxide to Cope with Iron Deficiency in Arabidopsis.
    Front Plant Sci, 2016. 7: p. 112
    [PMID:27014280]
  5. Zhou C, et al.
    Paenibacillus polymyxa BFKC01 enhances plant iron absorption via improved root systems and activated iron acquisition mechanisms.
    Plant Physiol. Biochem., 2016. 105: p. 162-173
    [PMID:27105423]
  6. Mai HJ,Pateyron S,Bauer P
    Iron homeostasis in Arabidopsis thaliana: transcriptomic analyses reveal novel FIT-regulated genes, iron deficiency marker genes and functional gene networks.
    BMC Plant Biol., 2016. 16(1): p. 211
    [PMID:27716045]
  7. Zhou C, et al.
    Exogenous Melatonin Improves Plant Iron Deficiency Tolerance via Increased Accumulation of Polyamine-Mediated Nitric Oxide.
    Int J Mol Sci, 2017.
    [PMID:27792144]
  8. Ezer D, et al.
    The G-Box Transcriptional Regulatory Code in Arabidopsis.
    Plant Physiol., 2017. 175(2): p. 628-640
    [PMID:28864470]
  9. Naranjo-Arcos MA, et al.
    Dissection of iron signaling and iron accumulation by overexpression of subgroup Ib bHLH039 protein.
    Sci Rep, 2017. 7(1): p. 10911
    [PMID:28883478]
  10. Kailasam S,Wang Y,Lo JC,Chang HF,Yeh KC
    S-Nitrosoglutathione works downstream of nitric oxide to mediate iron-deficiency signaling in Arabidopsis.
    Plant J., 2018. 94(1): p. 157-168
    [PMID:29396986]
  11. Cui Y, et al.
    Four IVa bHLH Transcription Factors Are Novel Interactors of FIT and Mediate JA Inhibition of Iron Uptake in Arabidopsis.
    Mol Plant, 2018. 11(9): p. 1166-1183
    [PMID:29960107]