PlantTFDB
Plant Transcription Factor Database
v5.0
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Rsa1.0_02220.1_g00001.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Raphanus
Family bHLH
Protein Properties Length: 566aa    MW: 62280.2 Da    PI: 4.8036
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Rsa1.0_02220.1_g00001.1genomeRGDView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH39.59.9e-13395440454
                              HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
                      HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                              +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  A+ YI++L
  Rsa1.0_02220.1_g00001.1 395 NHVEAERQRREKLNQRFYSLRAVVPNV-----SKMDKASLLGDAISYINEL 440
                              799***********************6.....5***************998 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142151.3E-5464252IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088817.282391440IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474593.93E-18394458IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000833.72E-15394445No hitNo description
Gene3DG3DSA:4.10.280.101.4E-18395459IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000103.6E-10395440IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.2E-16397446IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006952Biological Processdefense response
GO:0009718Biological Processanthocyanin-containing compound biosynthetic process
GO:0009753Biological Processresponse to jasmonic acid
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0043425Molecular FunctionbHLH transcription factor binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 566 aa     Download sequence    Send to blast
MDDHRSRVSL SPPDPHMSNY FLNQTTPPAD NDNAVEAFIG TNHWSQQTQP PPPQTLSQFN  60
EDTLQQRLQT LIESAGERWT YAIFWQISHE FDSPTGENTV ILGWGDGYYR GEEDKEKKKK  120
QSLSSNPAEQ EHRKRVIREL NSLIAGGGGA GVSDEANDEE VTDTEWFFLV SMTQSFVNGV  180
GLPGESFLNS RVIWLSGSGA LTGSGCERAR QGEVYGLQTI VCIAAENGVV ELGSSEVISQ  240
SSDLMDKVNG LFNGNGNGEA SSWGFNLNPD QGENDPALWL SEPNVTGIEP VVQETPPPGA  300
IENAGGDLNF SSSGLNQSGN FKQGSSSSKK RSPVVSKDEE MLSFTTVVRS AAKSVDSDHS  360
DIEASVVKEA IIVEPEKKPR KRGRKPANGR EEPLNHVEAE RQRREKLNQR FYSLRAVVPN  420
VSKMDKASLL GDAISYINEL KTKLQQAEAD KEEVQKQLDG MGKEGGGSRR AKERKSNRDS  480
ESSVEMEIDV KIIGWDVMIR VQCGKKNHPG ARFMEALKEL DLEVNHASLS VVNDLMIQQA  540
TVKMGSQFFN HDQLKAALML KVGEDI
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rru_A1e-1093424817227Transcription factor MYC3
4ywc_A1e-1093424817227Transcription factor MYC3
4ywc_B1e-1093424817227Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1376384KKPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor involved in tryptophan, jasmonic acid (JA) and other stress-responsive gene regulation. With MYC2 and MYC4, controls additively subsets of JA-dependent responses. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the G-box (5'-CACGTG-3') of promoters. Activates multiple TIFY/JAZ promoters. {ECO:0000269|PubMed:12136026, ECO:0000269|PubMed:21242320, ECO:0000269|PubMed:21321051, ECO:0000269|PubMed:21335373, ECO:0000269|PubMed:23943862}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00085PBMTransfer from AT5G46760Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapRsa1.0_02220.1_g00001.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Barely up-regulated by jasmonic acid. {ECO:0000269|PubMed:21242320, ECO:0000269|PubMed:21335373}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_018457039.10.0PREDICTED: transcription factor MYC3
SwissprotQ9FIP90.0MYC3_ARATH; Transcription factor MYC3
TrEMBLA0A397XV800.0A0A397XV80_BRACM; Uncharacterized protein
TrEMBLA0A3P6E5A00.0A0A3P6E5A0_BRAOL; Uncharacterized protein
STRINGBo9g065530.10.0(Brassica oleracea)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM12652896
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G46760.10.0bHLH family protein
Publications ? help Back to Top
  1. Chico JM, et al.
    Repression of Jasmonate-Dependent Defenses by Shade Involves Differential Regulation of Protein Stability of MYC Transcription Factors and Their JAZ Repressors in Arabidopsis.
    Plant Cell, 2014. 26(5): p. 1967-1980
    [PMID:24824488]
  2. Gasperini D, et al.
    Multilayered Organization of Jasmonate Signalling in the Regulation of Root Growth.
    PLoS Genet., 2015. 11(6): p. e1005300
    [PMID:26070206]
  3. Qi T, et al.
    Regulation of Jasmonate-Induced Leaf Senescence by Antagonism between bHLH Subgroup IIIe and IIId Factors in Arabidopsis.
    Plant Cell, 2015. 27(6): p. 1634-49
    [PMID:26071420]
  4. de Torres Zabala M, et al.
    Novel JAZ co-operativity and unexpected JA dynamics underpin Arabidopsis defence responses to Pseudomonas syringae infection.
    New Phytol., 2016. 209(3): p. 1120-34
    [PMID:26428397]
  5. Yu J, et al.
    JAZ7 negatively regulates dark-induced leaf senescence in Arabidopsis.
    J. Exp. Bot., 2016. 67(3): p. 751-62
    [PMID:26547795]
  6. Chen X,Huang H,Qi T,Liu B,Song S
    New perspective of the bHLH-MYB complex in jasmonate-regulated plant fertility in arabidopsis.
    Plant Signal Behav, 2016. 11(2): p. e1135280
    [PMID:26829586]
  7. Schmiesing A,Emonet A,Gouhier-Darimont C,Reymond P
    Arabidopsis MYC Transcription Factors Are the Target of Hormonal Salicylic Acid/Jasmonic Acid Cross Talk in Response to Pieris brassicae Egg Extract.
    Plant Physiol., 2016. 170(4): p. 2432-43
    [PMID:26884488]
  8. Thatcher LF, et al.
    Characterization of a JAZ7 activation-tagged Arabidopsis mutant with increased susceptibility to the fungal pathogen Fusarium oxysporum.
    J. Exp. Bot., 2016. 67(8): p. 2367-86
    [PMID:26896849]
  9. Gao C, et al.
    MYC2, MYC3, and MYC4 function redundantly in seed storage protein accumulation in Arabidopsis.
    Plant Physiol. Biochem., 2016. 108: p. 63-70
    [PMID:27415132]
  10. Gimenez-Ibanez S, et al.
    JAZ2 controls stomata dynamics during bacterial invasion.
    New Phytol., 2017. 213(3): p. 1378-1392
    [PMID:28005270]
  11. Zhang F, et al.
    Structural insights into alternative splicing-mediated desensitization of jasmonate signaling.
    Proc. Natl. Acad. Sci. U.S.A., 2017. 114(7): p. 1720-1725
    [PMID:28137867]
  12. Lian TF,Xu YP,Li LF,Su XD
    Crystal Structure of Tetrameric Arabidopsis MYC2 Reveals the Mechanism of Enhanced Interaction with DNA.
    Cell Rep, 2017. 19(7): p. 1334-1342
    [PMID:28514654]
  13. Wang H, et al.
    The bHLH Transcription Factors MYC2, MYC3, and MYC4 Are Required for Jasmonate-Mediated Inhibition of Flowering in Arabidopsis.
    Mol Plant, 2017. 10(11): p. 1461-1464
    [PMID:28827172]
  14. Song S, et al.
    MYC5 is Involved in Jasmonate-Regulated Plant Growth, Leaf Senescence and Defense Responses.
    Plant Cell Physiol., 2017. 58(10): p. 1752-1763
    [PMID:29017003]
  15. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]
  16. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]