PlantTFDB
Plant Transcription Factor Database
v5.0
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Rsa1.0_00770.1_g00008.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Raphanus
Family bHLH
Protein Properties Length: 216aa    MW: 24888.8 Da    PI: 5.479
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Rsa1.0_00770.1_g00008.1genomeRGDView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH35.12.3e-113881755
                             HHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                      HLH  7 erErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55
                             e+ErrRR+++ s++  Lr+++P       + ++Ka+i+e A+ YI +Lq
  Rsa1.0_00770.1_g00008.1 38 EAERRRREKLHSRLMALRSHVPIV-----TNMTKASIVEDAICYIGELQ 81
                             79*********************8.....69***************998 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000831.04E-102985No hitNo description
SuperFamilySSF474593.01E-153097IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088814.2273180IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.104.4E-123396IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.4E-123786IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000109.2E-93881IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0048658Biological Processanther wall tapetum development
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 216 aa     Download sequence    Send to blast
MGGGNRFQEP VRISRRRQVR KEKEEDEVNE SFKSPNLEAE RRRREKLHSR LMALRSHVPI  60
VTNMTKASIV EDAICYIGEL QKIVQNLTEK LHEMEEGPLE IDEQQTDHII KPEVETIVLK  120
EEMKKLGIEE NVQLCKIGER KFWLKITTEK KPGIFTKFMD VMSFMGFEII DITLATSNGA  180
IIICSSVQII QGLCDGDSVD LQQTKDFLLE VMRSNP
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
13944ERRRRE
24045RRRREK
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor. Involved in the control of tapetum development. Required for male fertility and pollen differentiation, especially during callose deposition. {ECO:0000269|PubMed:16831835}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00091SELEXTransfer from AT4G21330Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapRsa1.0_00770.1_g00008.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankEF1045306e-99EF104530.1 Brassica rapa clone E30_5 genomic sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_018468643.11e-157PREDICTED: transcription factor DYT1
SwissprotO819001e-116DYT1_ARATH; Transcription factor DYT1
TrEMBLM4DAK91e-138M4DAK9_BRARP; Uncharacterized protein
STRINGBra013519.1-P1e-139(Brassica rapa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM83582538
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G21330.11e-118bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Jiang J,Zhang Z,Cao J
    Pollen wall development: the associated enzymes and metabolic pathways.
    Plant Biol (Stuttg), 2013. 15(2): p. 249-63
    [PMID:23252839]
  3. Qian H, et al.
    Trace concentrations of imazethapyr (IM) affect floral organs development and reproduction in Arabidopsis thaliana: IM-induced inhibition of key genes regulating anther and pollen biosynthesis.
    Ecotoxicology, 2015. 24(1): p. 163-71
    [PMID:25348600]
  4. Shumin Z, et al.
    One novel cis-element is essential for correct DYSFUNCTIONAL TAPETUM 1 (DYT1) expression in Arabidopsis thaliana.
    Plant Cell Rep., 2015. 34(10): p. 1773-80
    [PMID:26134855]
  5. Cui J, et al.
    Feedback Regulation of DYT1 by Interactions with Downstream bHLH Factors Promotes DYT1 Nuclear Localization and Anther Development.
    Plant Cell, 2016. 28(5): p. 1078-93
    [PMID:27113773]
  6. Arkadir D, et al.
    DYT1 dystonia increases risk taking in humans.
    Elife, 2017.
    [PMID:27249418]
  7. Premi E, et al.
    Functional Connectivity Networks in Asymptomatic and Symptomatic DYT1 Carriers.
    Mov. Disord., 2016. 31(11): p. 1739-1743
    [PMID:27453152]
  8. Beauvais G, et al.
    Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis.
    J. Neurosci., 2016. 36(40): p. 10245-10256
    [PMID:27707963]
  9. Richter F,Gerstenberger J,Bauer A,Liang CC,Richter A
    Sensorimotor tests unmask a phenotype in the DYT1 knock-in mouse model of dystonia.
    Behav. Brain Res., 2017. 317: p. 536-541
    [PMID:27769743]
  10. Zhou S, et al.
    Function Identification of the Nucleotides in Key cis-Element of DYSFUNCTIONAL TAPETUM1 (DYT1) Promoter.
    Front Plant Sci, 2017. 8: p. 153
    [PMID:28261229]
  11. Li DD,Xue JS,Zhu J,Yang ZN
    Gene Regulatory Network for Tapetum Development in Arabidopsis thaliana.
    Front Plant Sci, 2017. 8: p. 1559
    [PMID:28955355]
  12. Ponterio G, et al.
    Enhanced mu opioid receptor-dependent opioidergic modulation of striatal cholinergic transmission in DYT1 dystonia.
    Mov. Disord., 2018. 33(2): p. 310-320
    [PMID:29150865]
  13. Gy├Ârgy B, et al.
    Mutant torsinA in the heterozygous DYT1 state compromises HSV propagation in infected neurons and fibroblasts.
    Sci Rep, 2018. 8(1): p. 2324
    [PMID:29396398]