PlantTFDB
Plant Transcription Factor Database
PlantRegMap/PlantTFDB v5.0
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Rsa1.0_00109.1_g00007.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Raphanus
Family bHLH
Protein Properties Length: 387aa    MW: 42801.5 Da    PI: 5.0234
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Rsa1.0_00109.1_g00007.1genomeRGDView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH34.24.5e-11130174655
                              HHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                      HLH   6 nerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                               + Er+RR r+++++  Lr l+P+      +K++Ka+i+  Av Y+++Lq
  Rsa1.0_00109.1_g00007.1 130 LISERKRRGRMKDKLYALRALVPNI-----TKMDKASIVGDAVAYVQELQ 174
                              578*********************7.....7******************9 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000838.48E-13117176No hitNo description
SuperFamilySSF474593.53E-16122189IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088815.37124173IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.105.8E-16126193IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000109.2E-9128174IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.2E-14130179IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0034756Biological Processregulation of iron ion transport
GO:0071281Biological Processcellular response to iron ion
GO:0071369Biological Processcellular response to ethylene stimulus
GO:0071732Biological Processcellular response to nitric oxide
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 387 aa     Download sequence    Send to blast
MEGTVNVLSN LSDIELHNFL VDPNFDQFIN LIRGDDQSNK NPSLDFDLGG PFQNSPSFVD  60
ENHFIPTHVD DLFDELPDLD SNVAESFRSL DAESVKAGGD DDYNDCEDSS ATTTHTDGSR  120
KTRTNRSKTL ISERKRRGRM KDKLYALRAL VPNITKMDKA SIVGDAVAYV QELQSQAKKL  180
KADIAGLEAS LNSTGGYQEP SPDAHKTRRG FNPPVSKKII QMDVIQVDEK GFYVRLVCNK  240
GEGVAPSLYK CLESLSSFEV QNSNLSSHSP DTYLLTYTLD VLLVCWKQGT CFEQSLNLPN  300
LKLWITGSLL NQGFLPILVI VSLALSQAVC ACAMVACHPC VVPALLLVSG KVSVWRVGFN  360
DESGARCQVE DLLTVRCSYL EQCRCFR
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor. Essential protein involved in iron uptake responses. Regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation. Confers enhanced iron mobilization responses at low iron supply. {ECO:0000269|PubMed:15539473, ECO:0000269|PubMed:15556641, ECO:0000269|PubMed:16117851}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapRsa1.0_00109.1_g00007.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: In roots by iron deficiency. Repressed by cytokinins. Induced by cold, UV, ethylene (ACC), jasmonic acid (JA), flagellin, and salicylic acid (SA) treatments. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:15531708, ECO:0000269|PubMed:15539473, ECO:0000269|PubMed:15556641, ECO:0000269|PubMed:18397377}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC2409850.0AC240985.1 Brassica rapa subsp. pekinensis cultivar Inbred line 'Chiifu' clone KBrB008O16, complete sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_018475437.10.0PREDICTED: transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR-like isoform X1
SwissprotQ0V7X40.0FIT_ARATH; Transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR
TrEMBLA0A078H1790.0A0A078H179_BRANA; BnaC03g46920D protein
TrEMBLA0A0D3B7A70.0A0A0D3B7A7_BRAOL; Uncharacterized protein
STRINGBo3g040310.10.0(Brassica oleracea)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM41872857
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G28160.11e-178FER-like regulator of iron uptake
Publications ? help Back to Top
  1. Schmid NB, et al.
    Feruloyl-CoA 6'-Hydroxylase1-dependent coumarins mediate iron acquisition from alkaline substrates in Arabidopsis.
    Plant Physiol., 2014. 164(1): p. 160-72
    [PMID:24246380]
  2. Doustaly F, et al.
    Uranium perturbs signaling and iron uptake response in Arabidopsis thaliana roots.
    Metallomics, 2014. 6(4): p. 809-21
    [PMID:24549117]
  3. Le CT, et al.
    ZINC FINGER OF ARABIDOPSIS THALIANA12 (ZAT12) Interacts with FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT) Linking Iron Deficiency and Oxidative Stress Responses.
    Plant Physiol., 2016. 170(1): p. 540-57
    [PMID:26556796]
  4. Yang L, et al.
    Carbon Monoxide Interacts with Auxin and Nitric Oxide to Cope with Iron Deficiency in Arabidopsis.
    Front Plant Sci, 2016. 7: p. 112
    [PMID:27014280]
  5. Zhou C, et al.
    Paenibacillus polymyxa BFKC01 enhances plant iron absorption via improved root systems and activated iron acquisition mechanisms.
    Plant Physiol. Biochem., 2016. 105: p. 162-173
    [PMID:27105423]
  6. Mai HJ,Pateyron S,Bauer P
    Iron homeostasis in Arabidopsis thaliana: transcriptomic analyses reveal novel FIT-regulated genes, iron deficiency marker genes and functional gene networks.
    BMC Plant Biol., 2016. 16(1): p. 211
    [PMID:27716045]
  7. Zhou C, et al.
    Exogenous Melatonin Improves Plant Iron Deficiency Tolerance via Increased Accumulation of Polyamine-Mediated Nitric Oxide.
    Int J Mol Sci, 2017.
    [PMID:27792144]
  8. Ezer D, et al.
    The G-Box Transcriptional Regulatory Code in Arabidopsis.
    Plant Physiol., 2017. 175(2): p. 628-640
    [PMID:28864470]
  9. Naranjo-Arcos MA, et al.
    Dissection of iron signaling and iron accumulation by overexpression of subgroup Ib bHLH039 protein.
    Sci Rep, 2017. 7(1): p. 10911
    [PMID:28883478]
  10. Kailasam S,Wang Y,Lo JC,Chang HF,Yeh KC
    S-Nitrosoglutathione works downstream of nitric oxide to mediate iron-deficiency signaling in Arabidopsis.
    Plant J., 2018. 94(1): p. 157-168
    [PMID:29396986]
  11. Cui Y, et al.
    Four IVa bHLH Transcription Factors Are Novel Interactors of FIT and Mediate JA Inhibition of Iron Uptake in Arabidopsis.
    Mol Plant, 2018. 11(9): p. 1166-1183
    [PMID:29960107]