PlantTFDB
Plant Transcription Factor Database
v5.0
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Rsa1.0_00030.1_g00001.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Raphanus
Family bHLH
Protein Properties Length: 206aa    MW: 23339 Da    PI: 9.3494
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Rsa1.0_00030.1_g00001.1genomeRGDView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH35.61.6e-11250455
                             HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                      HLH  4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55
                             +h ++Er+RR+++N+ +  Lr+l P     + k+ + a+i   ++e+Ik++q
  Rsa1.0_00030.1_g00001.1  2 SHIAVERNRRRQMNEHLKSLRSLTPCF---YIKRGDQASIIGGVIEFIKEMQ 50
                             89************************9...9*******************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000831.33E-10154No hitNo description
SuperFamilySSF474594.43E-15170IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088814.31149IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.1E-8250IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.101.3E-11261IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.5E-10455IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 206 aa     Download sequence    Send to blast
MSHIAVERNR RRQMNEHLKS LRSLTPCFYI KRGDQASIIG GVIEFIKEMQ QLVQVLESKK  60
RRKTLNQPSF LHDHQTLEPS ILAANTTTNA TTRVPFSRIE NVMSTSTFKE VGACCNSPHA  120
DVEAKISGSN VVLRVVSRRI EGQLVRIISA LEKLSFQVLH LNISSMEETV LYFFVVKIGL  180
ECRISLEELT VEVQRSFVPE VIVSTN
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
15862KKRRK
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor. Together with FMA and SPCH, regulates the stomata formation. Required for the differentiation of stomatal guard cells, by promoting successive asymmetric cell divisions and the formation of guard mother cells. Promotes the conversion of the leaf epidermis into stomata. {ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapRsa1.0_00030.1_g00001.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By UV, flagellin, and jasmonic acid (JA) treatments. {ECO:0000269|PubMed:12679534}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF4885801e-93AF488580.1 Arabidopsis thaliana clone bHLH045 putative bHLH transcription factor mRNA, partial sequence.
GenBankDQ4466391e-93DQ446639.1 Arabidopsis thaliana clone pENTR221-At3g06120 basic helix-loop-helix family protein (At3g06120) mRNA, complete cds.
GenBankDQ6530681e-93DQ653068.1 Arabidopsis thaliana clone 0000012753_0000009233 unknown mRNA.
GenBankDQ8636451e-93DQ863645.1 Arabidopsis thaliana helix-loop-helix protein (MUTE) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_018437486.11e-149PREDICTED: transcription factor MUTE-like
SwissprotQ9M8K61e-129MUTE_ARATH; Transcription factor MUTE
TrEMBLA0A078G2F41e-133A0A078G2F4_BRANA; BnaAnng03080D protein
TrEMBLM4FGK61e-133M4FGK6_BRARP; Uncharacterized protein
STRINGBra040234.1-P1e-134(Brassica rapa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM70732640
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G06120.11e-127bHLH family protein
Publications ? help Back to Top
  1. Casson S,Gray JE
    Influence of environmental factors on stomatal development.
    New Phytol., 2008. 178(1): p. 9-23
    [PMID:18266617]
  2. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  3. Balcerowicz M,Ranjan A,Rupprecht L,Fiene G,Hoecker U
    Auxin represses stomatal development in dark-grown seedlings via Aux/IAA proteins.
    Development, 2014. 141(16): p. 3165-76
    [PMID:25063454]
  4. de Marcos A, et al.
    Transcriptional profiles of Arabidopsis stomataless mutants reveal developmental and physiological features of life in the absence of stomata.
    Front Plant Sci, 2015. 6: p. 456
    [PMID:26157447]
  5. Mahoney AK, et al.
    Functional analysis of the Arabidopsis thaliana MUTE promoter reveals a regulatory region sufficient for stomatal-lineage expression.
    Planta, 2016. 243(4): p. 987-98
    [PMID:26748914]
  6. Klermund C, et al.
    LLM-Domain B-GATA Transcription Factors Promote Stomatal Development Downstream of Light Signaling Pathways in Arabidopsis thaliana Hypocotyls.
    Plant Cell, 2016. 28(3): p. 646-60
    [PMID:26917680]
  7. Fu ZW,Wang YL,Lu YT,Yuan TT
    Nitric oxide is involved in stomatal development by modulating the expression of stomatal regulator genes in Arabidopsis.
    Plant Sci., 2016. 252: p. 282-289
    [PMID:27717464]
  8. Qi X, et al.
    Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling.
    Elife, 2018.
    [PMID:28266915]
  9. Raissig MT, et al.
    Mobile MUTE specifies subsidiary cells to build physiologically improved grass stomata.
    Science, 2017. 355(6330): p. 1215-1218
    [PMID:28302860]
  10. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  11. Han SK, et al.
    MUTE Directly Orchestrates Cell-State Switch and the Single Symmetric Division to Create Stomata.
    Dev. Cell, 2018. 45(3): p. 303-315.e5
    [PMID:29738710]