PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID 28324.m000396
Common NameRCOM_0225530
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Acalyphoideae; Acalypheae; Ricinus
Family E2F/DP
Protein Properties Length: 451aa    MW: 49917 Da    PI: 5.4221
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
28324.m000396genomeJCVIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.61.9e-27155220171
        E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                    r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  28324.m000396 155 RYDSSLGLLTKKFVNLIKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 220
                    6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.1E-29152222IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.1E-34155220IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467858.43E-17155218IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.9E-24157220IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146605.62E-48234337No hitNo description
SuperFamilySSF1440741.12E-33234337No hitNo description
PfamPF164212.4E-33236335IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 451 aa     Download sequence    Send to blast
MSGSARASTR PPPTAAAAAA SASTPTPAPA GPILPPLRRH LAFATMKPPF VPPDDYHRFT  60
PSSSTNNRAA DREAEGIVLR SPTLKRKNGM DENGFESSSA FCGDVSNSPF RTPVSAKGGR  120
TYSKSKASKG NRSGPQTLVP NIDSPSPLTP AGSCRYDSSL GLLTKKFVNL IKHAEDGILD  180
LNKAAETLEV QKRRIYDITN VLEGIGLIEK KLKNRIRWKG VDTSRPGEPD GDASLLQAEI  240
EKLSMEERRL DDQTREMQER LRELIEDENN QKWLFVTEED IKSLPCFQNQ TLIAVKAPHG  300
TTLEVPDPDE AVDYPQRRYR IILRSSMGPI DVYLVSQFEE NFEEANGEPS TSFPHASSSC  360
SNEIPKKQVI NEQKIQKRVE PQMQQNDADY WLLSDADVSI TDMWRTDANV EWNDVNMLRA  420
DFGIPDVQTP RAQTPPSGMA EVPTGVNSTL R
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-25150221274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMap28324.m000396
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_025015055.10.0LOW QUALITY PROTEIN: transcription factor E2FA
SwissprotQ9FNY01e-165E2FA_ARATH; Transcription factor E2FA
TrEMBLB9SVY50.0B9SVY5_RICCO; E2F4,5, putative
STRINGXP_002530154.10.0(Ricinus communis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-165E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]