PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Prupe.7G098100.1.p
Common NamePRUPE_ppa005262mg
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Amygdaleae; Prunus
Family E2F/DP
Protein Properties Length: 471aa    MW: 51887.9 Da    PI: 4.9368
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Prupe.7G098100.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.22.5e-27145210171
             E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                         r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  Prupe.7G098100.1.p 145 RYDSSLGLLTKKFINLIKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 210
                         6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.8E-29142212IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467855.08E-17145208IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.0E-34145210IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.4E-24147210IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440745.49E-34223327No hitNo description
CDDcd146604.33E-50223327No hitNo description
PfamPF164218.2E-34226325IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 471 aa     Download sequence    Send to blast
MSGCARAPNR QPTPATAATA GGTQILPPLR RHLAFESTKP QPFPPDNYHR FAGGARRAGD  60
HEPEAIHVRS PQLTRKDNNE VEYSDWTSSP GYTNVVQSPL QTPMSTKGGR INNRSKASKG  120
NRSGPQTPVS NAGSPSPLTP AGSCRYDSSL GLLTKKFINL IKHAEDGILD LNKAAETLEV  180
QKRRIYDITN VLEGIGLIEK KLKNRIRWKG FDASRPGELD GDLSILQAEV ENLSLKERTL  240
DDQIREMQEK LRDLSEDENN RKWLFVTEED IKAIPCFHNE TLIAIKAPHG TTLEVPDPDE  300
AVDYPQRRYR IILRSTMGPI DVYLVSQFEE KFEDINGAEP PVSFPIASGS GSNEHPTTEV  360
ITVESSGKEI EPWAQQADQT CSDINTSQEF AGGMMKIVPS DVDNDADYWL LSDAEVSITD  420
MWRTDSGVGW NGADILHSDF GVPDVSITRP QTPPSGIAEI PPHAVNFSQR *
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A5e-24140211274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapPrupe.7G098100.1.p
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_007204334.10.0transcription factor E2FA
SwissprotQ9FNY00.0E2FA_ARATH; Transcription factor E2FA
TrEMBLM5W8E60.0M5W8E6_PRUPE; Uncharacterized protein
STRINGEMJ055330.0(Prunus persica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.10.0E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]