PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Prupe.6G139900.1.p
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Amygdaleae; Prunus
Family E2F/DP
Protein Properties Length: 464aa    MW: 51243.2 Da    PI: 4.5702
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Prupe.6G139900.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP85.93.1e-27143208171
             E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                         r ++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Prupe.6G139900.1.p 143 RFDSSLGLLTKKFINLIKHAEDGILDLNNAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 208
                         6789******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.2E-28141210IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467855.71E-17143206IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.7E-34143208IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.6E-24145208IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440741.15E-33220325No hitNo description
CDDcd146603.65E-48223325No hitNo description
PfamPF164212.9E-33224323IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 464 aa     Download sequence    Send to blast
MSGSRAHDPP AQPPQPIMQQ ALKRQLAFSS MKPPFSATAD YHGFVPDPRQ LTDSEAYGIY  60
VKPSQQKRKS DAADYEAESS DRTAAPGYTE VVTSPLQTPV SSKVGKANKT SRLTKCSRSG  120
PQTPASNVGS PSGANLTPAG PCRFDSSLGL LTKKFINLIK HAEDGILDLN NAADTLEVQK  180
RRIYDITNVL EGIGLIEKKL KNRIQWKGLD VSRTGDVDEN YPSLQAQVEN LSDEERRLDQ  240
QIREMQERLR DLSEDESNKK WLFVTEEDIK GLPCLQNETL IAIKAPHGTT LEVPDPDEAV  300
DYPQRRYRMV LRSTMGPIDV YLVSQFEEKF EEINGVEVPT DIPSSSGVNE NPATTMVTEN  360
RGKDVEIQGP DDHRMCADPT ASQDIMSGMM KIVPSDVDSD ADYWLLSDAD ISITDMWRTE  420
PGVVWNELGA IDEDYMVNVS TPRPQTPPSS STQVPATANR TKT*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-26138209274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant at the G1/S transition. Lower but constant level in the following phases. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:16514015}.
UniprotTISSUE SPECIFICITY: Expressed in proliferating cells and several differentiated tissues. Detected in inflorescence and shoot apical meristems, cotyledonary vascular tissues, leaf primordia, young leaves, base of trichomes, central cylinder and elongation zone of roots, lateral root primordia, flowers, pistils of immature flowers and pollen grains. {ECO:0000269|PubMed:16514015}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapPrupe.6G139900.1.p
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_020422980.10.0transcription factor E2FB isoform X1
SwissprotQ9FV711e-152E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A251NQ630.0A0A251NQ63_PRUPE; Uncharacterized protein
STRINGEMJ094780.0(Prunus persica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-151E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]