PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Pp3c2_30010V3.1.p
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Bryophyta; Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrella
Family E2F/DP
Protein Properties Length: 469aa    MW: 51532.9 Da    PI: 4.6496
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Pp3c2_30010V3.1.pgenomeCOSMOSSView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.52e-27142207171
            E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                        r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  Pp3c2_30010V3.1.p 142 RYDSSLGLLTKKFIDLIKQAEDGVLDLNKAADTL---HV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 207
                        6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.7E-29138208IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467859.98E-18142205IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013728.0E-35142207IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023197.7E-25144207IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440741.46E-31222323No hitNo description
PfamPF164213.6E-33223322IPR032198E2F transcription factor, CC-MB domain
CDDcd146607.07E-48223323No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 469 aa     Download sequence    Send to blast
MEILRPDALK IASYPGFGSD VTMPHQQAPT WMVMQSGKPK IDPMEINDLL YANVGVDDVP  60
LTLANGFEMK RRNECEEHHV EMNGWNGYAN SDLSPAPTPT GPRGRASRPK TVKQTKNGPQ  120
TPGPSGIGSP TSSAPTPTST CRYDSSLGLL TKKFIDLIKQ AEDGVLDLNK AADTLHVQKR  180
RIYDITNVLE GIGLIEKKLK NRIRWKGLGM VRTTEGKDDA VGLQVEVEDL RNEEKKLDES  240
ISEMRERLRS LSEDDHNKQW LYVTEDDIKN LPCFQNETLI AIKAPLGTTL EVPDPDEAVE  300
YPHRRFQILL RSTMGPIDVY LVSRFEGRTE VPMEPLPGSQ EAGPSTTANA MDHQGNMAMV  360
PEVGYGLSDL VPPANHEAAS QTSEPTSSHP DFVGGIMRIA PAEGNTDSDY WLLSDAGVGI  420
SDMWRSDPSN AMWDEVVRLN TEFGIENIGS PRPHTPPSSN ALEVDPVS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A6e-26137209275PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Ppa.36050.0protonema
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB5473390.0AB547339.1 Physcomitrella patens E2F;3 mRNA for E2F transcription factor;3, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024368554.10.0transcription factor E2FA-like isoform X1
SwissprotQ9FNY01e-103E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A2K1L3L30.0A0A2K1L3L3_PHYPA; Uncharacterized protein
STRINGPP1S22_60V6.10.0(Physcomitrella patens)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP12251749
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-101E2F transcription factor 1
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]