PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_008243467.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Amygdaleae; Prunus
Family E2F/DP
Protein Properties Length: 470aa    MW: 51847.8 Da    PI: 4.8208
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_008243467.1genomeBGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.22.5e-27145210171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  XP_008243467.1 145 RYDSSLGLLTKKFINLIKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 210
                     6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.8E-29142212IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.0E-34145210IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.81E-17145208IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023192.4E-24147210IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440744.97E-33223327No hitNo description
CDDcd146602.70E-48223327No hitNo description
PfamPF164215.7E-33226325IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 470 aa     Download sequence    Send to blast
MSSCARAPNR QPTPATAATA GGTQILPPLR RHLAFESTKP QPFPPDNYHR FAGSARGVGD  60
QEPEAIHVRS PQLTRKDNNE VEYSDWTSSP GYTNVVQSPL QTPVSTKGGR INNRSKASKG  120
NRSGPQTPVS NAGSPSPLTP AGSCRYDSSL GLLTKKFINL IKHAEDGILD LNKAAETLEV  180
QKRRIYDITN VLEGIGLIEK KLKNRIRWKG FDASRPGELD GDLSILQVEV ENLSLKERTL  240
DDQIREMQEK LRDLSEDENN RKWLFVTEED IKALPCFHNE TLIAIKAPHG TTLEVPDPDE  300
AVDYPQRRYR IILRSTMGPI DVYLVSQFEE KFEDINGAEP PVSFPIASGS VSNEHPTTEV  360
ITVESSGKEI EPWAQQADQT CSDINASQEF AGGIMKIVPS DVDNDADYWL LSDAEVSITD  420
MWRTDSGVGW NGADILHSDF GVSDVSITRP QTPPSGIAEI PPHAVNFSQR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A5e-24140211274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_008243467.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008243467.10.0PREDICTED: transcription factor E2FA
SwissprotQ9FNY00.0E2FA_ARATH; Transcription factor E2FA
TrEMBLM5W8E60.0M5W8E6_PRUPE; Uncharacterized protein
STRINGXP_008243467.10.0(Prunus mume)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.10.0E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]