PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID PH01000448G0580
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; BOP clade; Bambusoideae; Arundinarodae; Arundinarieae; Arundinariinae; Phyllostachys
Family bHLH
Protein Properties Length: 410aa    MW: 43760.8 Da    PI: 5.1736
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PH01000448G0580genomeICBRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH41.72.1e-13181232155
                      CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
              HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                      +r++h ++Er+RR+++N+ +  Lr+l+P +   + ++ + a+i+  A+e+I++L+
  PH01000448G0580 181 QRMTHIAVERNRRRHMNEYLGVLRSLVPGS---YVQRGDQATIVGGAIEFIRELE 232
                      79****************************...9******************996 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000834.42E-14179236No hitNo description
Gene3DG3DSA:4.10.280.107.3E-14179235IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474591.27E-16180245IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088815.44180231IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000108.2E-11181232IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003538.5E-10186237IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd048738.30E-4335393No hitNo description
PROSITE profilePS5167110.478335409IPR002912ACT domain
SuperFamilySSF550211.77E-5335405No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008152Biological Processmetabolic process
GO:0016597Molecular Functionamino acid binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 410 aa     Download sequence    Send to blast
MDKDQQRRHQ QLDSFAPLDG APEEPGGGGG VAGAGMVDYM VGQAPPPRGP QRQVSFDKLS  60
FSDVLQFADF GPKLALNQPT ASADHNDVDD DDDDDSYFLR FQSLPSLPAA PPRGGAHHVE  120
QEGSRTVDGG AHDVGGVSES TTLVQQPDGG GRADQKGGDQ GKSGRRKRPR TIKTSEEVES  180
QRMTHIAVER NRRRHMNEYL GVLRSLVPGS YVQRGDQATI VGGAIEFIRE LEQLIQCLES  240
QKRRRLYGGS GDAPRSVADG AGAPPSMQQQ PQQGQAPAFY PPSLPFSAAS GGGSDGAAAK  300
MLDLDAAGGG PREEVAENKS CLADIEVRVL GVDAMIKILS RRRPGLLIKI IAALEDTQMS  360
ILHTNITTIE QTVLYSFNVK IAGEARFSAE DIAGAVHQIL SFVDVNYAL*
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1181192RMTHIAVERNRR
2241245KRRRL
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapPH01000448G0580
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKJ7277501e-101KJ727750.1 Zea mays clone pUT5691 bHLH transcription factor (bHLH22) mRNA, partial cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_025805324.10.0transcription factor FAMA isoform X1
SwissprotQ56YJ81e-108FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A0A9GYP10.0A0A0A9GYP1_ARUDO; FMA
STRINGPavir.J03740.1.p0.0(Panicum virgatum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP95023340
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.11e-103bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]