PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Pahal.C01762.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Panicoideae; Panicodae; Paniceae; Panicinae; Panicum
Family bHLH
Protein Properties Length: 424aa    MW: 44740.6 Da    PI: 4.9885
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Pahal.C01762.1genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH41.32.8e-13187238155
                     CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
             HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                     +r++h ++Er+RR+++N+ +  Lr+l+P +   + ++ + a+i   A+e+I++L+
  Pahal.C01762.1 187 QRMTHIAVERNRRRQMNEYLRILRSLMPGS---YVQRGDQASIIGGAIEFIRELE 238
                     79****************************...9******************996 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:4.10.280.102.5E-13185241IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000837.74E-14185242No hitNo description
PROSITE profilePS5088815.847186237IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474591.13E-16186251IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.1E-10187238IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.0E-9192243IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS516718.994349423IPR002912ACT domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010377Biological Processguard cell fate commitment
GO:0045597Biological Processpositive regulation of cell differentiation
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051782Biological Processnegative regulation of cell division
GO:0005634Cellular Componentnucleus
GO:0016597Molecular Functionamino acid binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 424 aa     Download sequence    Send to blast
MDKEQGSHHS HLDSFTPLDG AAPGDQTGGG AEMVDYILGQ APPPAQPPPP QSQVSFDKLS  60
FSDVLQFADF GPKLALNQPA ASAGAHEGVD DPGDDEDDDD GYFFRFQSLS SLPGGAGQHH  120
ADREGSKTTA DDGGAHDGGG GGGVSESTTL VQHADGGGRA EKGGDQGKSG RRKRPRTVKT  180
SEEVESQRMT HIAVERNRRR QMNEYLRILR SLMPGSYVQR GDQASIIGGA IEFIRELEQL  240
IQCLESQKRR RLYGGSGDAP RPVVDAAGAG APTSTQQHHQ TQVPPAAAFF PPSLPFPVAS  300
SGGGDGGAAK ILDLEAGGAD AAAGLREEVA ENKSCLADIE VRALGADAMI KILSRRRPGQ  360
LIKTIAALED MQMSILHTNI TTIEQTVLYS FNVKILGEAR YSAEDIAGAV HQILSFIDVN  420
YAL*
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1187198RMTHIAVERNRR
2247251KRRRL
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKJ7277501e-137KJ727750.1 Zea mays clone pUT5691 bHLH transcription factor (bHLH22) mRNA, partial cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_025805324.10.0transcription factor FAMA isoform X1
SwissprotQ56YJ81e-112FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A2S3H9I30.0A0A2S3H9I3_9POAL; Uncharacterized protein
TrEMBLA0A2T7E9Q90.0A0A2T7E9Q9_9POAL; Uncharacterized protein
STRINGPavir.J04021.1.p0.0(Panicum virgatum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP95023340
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.19e-54bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]