PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID CCG005686.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Salicaceae; Saliceae; Populus
Family E2F/DP
Protein Properties Length: 457aa    MW: 49952.9 Da    PI: 4.8846
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
CCG005686.1genomeLZUView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP84.86.7e-27146211171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  r+++sL+llt++f++l++++++gi++ln++a++L   +v  ++RRiYDi+NVLe+++liek+ kn+irwkg
  CCG005686.1 146 RYDSSLGLLTKRFVDLFKHADDGILDLNNAAETL---EV--QKRRIYDITNVLEGIGLIEKTLKNRIRWKG 211
                  6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.3E-28143213IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467854.08E-17146209IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.5E-34146211IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023195.0E-24148211IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440741.1E-30225328No hitNo description
CDDcd146605.19E-47227328No hitNo description
PfamPF164213.6E-32227326IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 457 aa     Download sequence    Send to blast
MSGSAKASTR PAAQPPPSGP IQPPLTRQLA FATMKPSFVP PDDYHRFSSP STSRVTADRD  60
AEAIVVRSPQ LKRKSALDDN GVGSSNRASS PGSTSISNIP FRTPVSAKAG RTYNKSKASK  120
GSGAGPQTPV SKADCASPLT PAGSCRYDSS LGLLTKRFVD LFKHADDGIL DLNNAAETLE  180
VQKRRIYDIT NVLEGIGLIE KTLKNRIRWK GIDASRPGQV EGDATLLQAE IAKLTMEELT  240
LDDQIREMQE RLRDLSEDEN NQKRLFVTEE DIKSLPCFLN ETLIAIKAPH GTTLEVPDPD  300
EAVDYPQRRY RIILRSSMGP IDVYLVSQFE ENFEEMNNVE TSVSIPLASI SASHGNPMTE  360
MTTDVRTQGR SGSLAQQAQT MFSDPNTTQE LGGMMKIVPS DVHDDSDYWL LSDAGISITD  420
MWKTDSNTEW ADFGVTDVQT PRTQTPLHGI TEVPPGV
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-23141212274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011046879.10.0PREDICTED: transcription factor E2FA-like
SwissprotQ9FNY01e-157E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A2K2A5E00.0A0A2K2A5E0_POPTR; Uncharacterized protein
STRINGPOPTR_0006s22150.10.0(Populus trichocarpa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-153E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]