PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Pbr015398.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Pyrus
Family E2F/DP
Protein Properties Length: 481aa    MW: 53158.6 Da    PI: 5.3827
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Pbr015398.1genomeCPETRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP85.93.1e-27155220171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  Pbr015398.1 155 RYDSSLGLLTKKFINLIKRAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 220
                  6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.105.2E-29152222IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.05E-16155218IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.5E-34155220IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.5E-24157220IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440744.97E-34233337No hitNo description
CDDcd146601.17E-48233337No hitNo description
PfamPF164216.7E-33236335IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 481 aa     Download sequence    Send to blast
MSGCARAPNR QPAPATAGTG GGGPILPPLR RHXXXXLPPL RRHLAFESTK PQPFPPDNYH  60
RFAGGARRAG DQEPEDIYVR SPQLTRKDNN EVEYSDWTCS PGNTNIIQSP LLTPPMSAKG  120
GRVNNRSKAS KGGRSGPQTP VSNVGSPSTP AGSCRYDSSL GLLTKKFINL IKRAEDGILD  180
LNKAAETLEV QKRRIYDITN VLEGIGLIEK KLKNRIRWKG FDASMPGELD GDLSILQAEV  240
ENLSLQERRL DDRIREMQEK LRDLSEDENN QKWLFVTEDD IKGLPCFHNE TLIAIKAPHG  300
TTLEVPDPDE AVDYPRRRYR IILRSTMGPI DVYLVSQFEE KFEDVHGAEP PVSFPMASVS  360
GSSEHPITEV VTVESSGKEI EPWPQQAHHL CSDLNASQEF AGGMMKIVPS DVDNDADYWL  420
LSDAEVSITD MWRTDSGVGW NGTDILHADF GVTDVSTPRP QTPPSRVVEV PSHAVNFAQR  480
*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-24147221274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapPbr015398.1
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009372588.20.0PREDICTED: transcription factor E2FA-like
SwissprotQ9FNY01e-169E2FA_ARATH; Transcription factor E2FA
TrEMBLM5W8E60.0M5W8E6_PRUPE; Uncharacterized protein
STRINGXP_009372588.10.0(Pyrus x bretschneideri)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-173E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]