PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Pbr011903.3
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Pyrus
Family E2F/DP
Protein Properties Length: 535aa    MW: 58834.3 Da    PI: 4.7154
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Pbr011903.3genomeCPETRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP85.93e-27142207171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  r ++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Pbr011903.3 142 RFDSSLGLLTKKFINLIKHAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 207
                  6789******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.109.8E-29140209IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467857.35E-17142205IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.1E-34142207IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.5E-24144207IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440743.92E-32219324No hitNo description
CDDcd146608.80E-47222324No hitNo description
PfamPF164211.1E-31223322IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 535 aa     Download sequence    Send to blast
MSGSRAPNPP AQPPQPVMQQ PLKRQLPFSS MKPPFSAAAD YHGFLPDPRQ TTDQETYGIT  60
VKTPLKRKSD AVDCEAESSD RTTAPGYTDV GNSLLQTPMS TKVGKANKTS RLTKCSKSGP  120
RTPASNVGSP SGANVTPAGP CRFDSSLGLL TKKFINLIKH AEDGILDLNK AADTLEVQKR  180
RIYDITNVLE GIGLIEKKLK NRIQWKGLDV SRTGDVDENY PSLQAQLENL SIEERRLDQQ  240
IREMQERLRD LSVDESNKKW LFVTEEDIKG LPCLQNETLI AIKAPHGTTL EVPDPDEAVD  300
YPQRRYRMVL RSTMGPIDVY LVSQFEEKFE EINGVEVPAN IPATSGANEN PATTMVSEDR  360
GKDVELQVPD DHTMSADPTA AQDFTGGIMK IVPSDVDSDT DYWLLSDADI SITDLWRTER  420
ILVPKDVIFL FTEFSLCLYL TGKQFLWVNF LTISTIAGVL WNDLGALDHD YPLGSGSCPS  480
VPGRPIEGTR NNVMVGGESN QQAFVGVTGV KKAGYRRIEN QSLDINAGAD ECIT*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-26137208274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapPbr011903.3
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009369919.10.0PREDICTED: transcription factor E2FB isoform X2
SwissprotQ9FV711e-144E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A498KBY80.0A0A498KBY8_MALDO; Uncharacterized protein
STRINGXP_009369918.10.0(Pyrus x bretschneideri)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.31e-146E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]