PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Pbr010366.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Pyrus
Family E2F/DP
Protein Properties Length: 430aa    MW: 47527.1 Da    PI: 4.6161
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Pbr010366.1genomeCPETRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.12.6e-27104169171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  Pbr010366.1 104 RYDSSLGLLTKKFINLIKRAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 169
                  6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.4E-29101171IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467855.89E-17104167IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.5E-34104169IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.3E-24106169IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.90E-49182286No hitNo description
SuperFamilySSF1440746.28E-34182286No hitNo description
PfamPF164215.1E-33185284IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 430 aa     Download sequence    Send to blast
MCCLIWSEGT DLEVDFQVVV FGSFLESIVA HGQLTRKDNN EVGYSDWTNS PGNTNVIQSP  60
LQTPVSAKGG RVNNRSKASK GGRSGPQTPV SIVGSPSTPA GSCRYDSSLG LLTKKFINLI  120
KRAEDGILDL NKAAETLEVQ KRRIYDITNV LEGIGLIEKK LKNRIRWKGF DASMPGELDG  180
DLSILQAEVE NLSSQERRLD DRIREMQEKL RDLSEDENNR KWLFVTEDDI KGLPCFHNET  240
LIAIKAPHGT TLEVPDPDEA VDYPQRRYRI ILRSTMGPID VYLVSQFEEK FEDVHGAEPP  300
VNFPIASGSG SNEHPTTEVV TVESSGKEIE PWLQQAHHAC SDMNASQEFA GGMMKIVPSD  360
VDNDADYWLL SDAEVSITDM WRTDSGVGWN GTDILHADFG VTDVSTSRPQ TPPSRVVEVP  420
SHAVNFAQR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-2496169273PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapPbr010366.1
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009349221.10.0PREDICTED: transcription factor E2FA-like
SwissprotQ9FNY01e-154E2FA_ARATH; Transcription factor E2FA
TrEMBLM5W8E60.0M5W8E6_PRUPE; Uncharacterized protein
STRINGXP_009349217.10.0(Pyrus x bretschneideri)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-159E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]