PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Peaxi162Scf00755g00019.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Petunioideae; Petunia
Family E2F/DP
Protein Properties Length: 436aa    MW: 48206.7 Da    PI: 4.5737
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Peaxi162Scf00755g00019.1genomeSGNView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.32.4e-27115180171
                   E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                               r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Peaxi162Scf00755g00019.1 115 RYDSSLGLLTKKFINLIKHAEDGVLDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 180
                               6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.3E-29113182IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.2E-35115180IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.81E-17115178IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.1E-24117180IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146606.65E-47191297No hitNo description
SuperFamilySSF1440741.12E-32193297No hitNo description
PfamPF164217.9E-33196295IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 436 aa     Download sequence    Send to blast
MNRQQLPLTS TKPPFGDYHR FSTDQIHQET EGIVVKSTPL KRKNEAANYE HGVGAQIAGS  60
GYADVSSPMQ TPISGKAGKA QKVPRTSKAR AASQAATSIL GSPSGNNVTP VGPCRYDSSL  120
GLLTKKFINL IKHAEDGVLD LNKAADTLEV QKRRIYDITN VLEGIGLIEK KLKNRIQWKG  180
LDVSRPGEVD DSVTSLQADV ENLAIEERRV DEKIREMQER LRDLSEDENN QRWLFVTEDD  240
IKSLPCFQNE TLIAIKAPHG TTLEVPDPDE AVDYPQRRYR IVLRSTMGPI DVYLVSQFEE  300
KFEEINAVEA PPRLPSTSGC NENATATLPT EESRGVDSGM EEKENERVCP DVSTSQDFAS  360
GIMKIVPDVD NEADYWLLSD AANISITDMW RTESVLDWSE LNAIHEDYSM ANVSTPRAQT  420
PPSSTTELPS ANTSGS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A8e-27110181274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0253470.0AB025347.1 Nicotiana tabacum mRNA for transcription factor, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009800733.10.0PREDICTED: transcription factor E2FB-like isoform X2
RefseqXP_016473683.10.0PREDICTED: transcription factor E2FB-like
SwissprotQ9FV711e-155E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A1S4AAL50.0A0A1S4AAL5_TOBAC; transcription factor E2FB-like
TrEMBLA0A1U7YC730.0A0A1U7YC73_NICSY; transcription factor E2FB-like isoform X2
STRINGXP_009623945.10.0(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-158E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]