PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Peaxi162Scf00224g00820.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Petunioideae; Petunia
Family E2F/DP
Protein Properties Length: 434aa    MW: 47851.1 Da    PI: 4.4328
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Peaxi162Scf00224g00820.1genomeSGNView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.81.6e-27125190171
                   E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                               r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Peaxi162Scf00224g00820.1 125 RYDSSLGLLTKKFINLIKQAEDGILDLNNAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 190
                               6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.8E-29123192IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.54E-17125188IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.9E-34125190IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.2E-24127190IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146608.70E-48201307No hitNo description
SuperFamilySSF1440743.14E-32203307No hitNo description
PfamPF164218.0E-33206305IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 434 aa     Download sequence    Send to blast
MQNQHQQKQS LKPQLQFSLN KPVFGDYHRF SSDSFNQQPV PGIVVKTPPL KRKSVAANYG  60
QGVGDQNPVT GYANVNSPVQ TPVSGKAGNA QKVPRTSKAR STSQAVASNI GSPSGNNVTP  120
GGPCRYDSSL GLLTKKFINL IKQAEDGILD LNNAADTLEV QKRRIYDITN VLEGIGLIEK  180
KLKNRIQWKG LDVSKPGEAD DSVASLQAEV ENLTIEEHRV DEQIREMQEK LRDLSEDENN  240
QRWLFVTEGD IKSLPCLQNE TLIAIKAPHG TTLEVPDPDE AVDYPQRRYR IVLRSTMGPI  300
DVYLVSQFEE KFEEINADEA PPSVPSTSGL NENVTATLAT EENRVDTGME EKENQRVCSD  360
VGTSQDFVSG IMKIVPDDNE ADYWFFSDAG AAIDWNELDA IQEDYSIANV STPRSSTPPP  420
NTTEVPSEAN TTEC
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-28120191274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT0128400.0BT012840.1 Lycopersicon esculentum clone 113908F, mRNA sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006362858.10.0PREDICTED: transcription factor E2FB
SwissprotQ9FV711e-147E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A0V0II580.0A0A0V0II58_SOLCH; Putative transcription factor E2FB-like
STRINGXP_009802122.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-149E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]