PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MA_66734g0010
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Acrogymnospermae; Pinidae; Pinales; Pinaceae; Picea
Family E2F/DP
Protein Properties Length: 388aa    MW: 43018.2 Da    PI: 4.2406
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MA_66734g0010genomeConGenIEView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP82.92.6e-2675140171
        E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                    r+++sL+llt+kf++l++++++gi++ln++a++L   +v  ++RRiYDi+NVLe+++liek+ kn+i wkg
  MA_66734g0010  75 RYDSSLGLLTKKFISLVKQADDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKRLKNRICWKG 140
                    6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.2E-2872141IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.45E-1775138IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013728.7E-3475140IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023195.7E-2477140IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146603.78E-51151257No hitNo description
SuperFamilySSF1440744.97E-34152257No hitNo description
PfamPF164213.2E-34156255IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 388 aa     Download sequence    Send to blast
MTETEEHEME SNELPSGHGY VEADTIAINT AVSGTGGRRY NRSKLAKRAK IGPQTPGSNI  60
GSPLGNAPTP ISSCRYDSSL GLLTKKFISL VKQADDGILD LNKAADTLEV QKRRIYDITN  120
VLEGIGLIEK RLKNRICWKG LSVSRPGEVE DEATVLQAEV DSLYSEECKL DECIRDMQER  180
LRILSEDERN RRWLYVTDED IKNLPCFQND TLIAIKAPHG TTLEVPDPDE AVEYPQRRYQ  240
ILLRSTMGPI DVYLVSQFEE NIEEMNPVDL ATELVPSGTC PAEGVPIPNV QEGVTSVEME  300
CQGRETRQLC TELTSPQDSV GGIKRIVPSD ANIDADYWLL LDSGVGITDM WRTETNPTWD  360
EVIELNPTDF GIGEGSPCPQ TPPSSSVF
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A8e-2570141274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankJN8354630.0JN835463.1 Pinus sylvestris E2F-like protein mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021278200.11e-163transcription factor E2FB isoform X2
SwissprotQ9FV711e-125E2FB_ARATH; Transcription factor E2FB
TrEMBLH6VN380.0H6VN38_PINSY; E2F-like protein
STRINGXP_010262959.11e-162(Nelumbo nucifera)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP12251749
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-127E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]