PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MA_13142g0010
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Acrogymnospermae; Pinidae; Pinales; Pinaceae; Picea
Family E2F/DP
Protein Properties Length: 255aa    MW: 28768.2 Da    PI: 4.7362
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MA_13142g0010genomeConGenIEView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP85.92.9e-2782146170
        E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwk 70 
                    r+++sL+llt+kf++l++++++g+++ln++a++L   dv  ++RRiYDi+NVLe+++liekk kn+irwk
  MA_13142g0010  82 RYDSSLGLLTKKFISLIKQADDGVLDLNKAADTL---DV--QKRRIYDITNVLEGIGLIEKKLKNRIRWK 146
                    6899******************************...**..****************************7 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.107.1E-2879146IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467859.87E-1882145IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.8E-3282147IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.9E-2484146IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.10E-36152237No hitNo description
SuperFamilySSF1440743.4E-27153244No hitNo description
PfamPF164214.6E-24157234IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 255 aa     Download sequence    Send to blast
MSLGKRRAET EEDHEIESNE WPTSQGYAEA VNSPILTPVS GTSGRRYNRS KLAKSMRTGP  60
QTPASNIGSP SSNVHTPVST CRYDSSLGLL TKKFISLIKQ ADDGVLDLNK AADTLDVQKR  120
RIYDITNVLE GIGLIEKKLK NRIRWKPGEV DDEVTSLQAE VENLYVEERR VDEKIREMRE  180
RLRILSEDEN NQKWLYVTEE DIKSLPCFQN ETLIAIKAPH GTTLEVPDPD EVSFDFQNIC  240
SPLQSSIGVQ GYLDD
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A7e-2677146272PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT1228150.0BT122815.1 Picea sitchensis clone WS0461_J06 unknown mRNA.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010246568.11e-121PREDICTED: transcription factor E2FA
SwissprotQ9FV712e-87E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A200Q9I61e-121A0A200Q9I6_9MAGN; Transcription factor E2F/dimerization partner (TDP)
STRINGXP_010246568.11e-120(Nelumbo nucifera)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP12251749
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.36e-90E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]