PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Oropetium_20150105_03723A
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Chloridoideae; Cynodonteae; Tripogoninae; Oropetium
Family bHLH
Protein Properties Length: 384aa    MW: 41950.5 Da    PI: 9.6015
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Oropetium_20150105_03723AgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH40.93.6e-13151202155
                                CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                        HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                                +r++h ++Er+RR+++N+ +  Lr+l+P +   + ++ + a+i   A+e+I++L+
  Oropetium_20150105_03723A 151 QRMTHIAVERNRRRQMNEYLRVLRSLMPGS---YVQRGDQASIIGGAIEFIRELE 202
                                79****************************...9******************996 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000831.11E-12149206No hitNo description
Gene3DG3DSA:4.10.280.101.1E-13149205IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088815.897150201IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474598.77E-17150216IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.5E-10151202IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.0E-9156207IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS516719.56309383IPR002912ACT domain
SuperFamilySSF550217.79E-5309377No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010377Biological Processguard cell fate commitment
GO:0045597Biological Processpositive regulation of cell differentiation
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051782Biological Processnegative regulation of cell division
GO:0005634Cellular Componentnucleus
GO:0016597Molecular Functionamino acid binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 384 aa     Download sequence    Send to blast
MDKEQHHHQA TAHNSRRFVD SFAPLDGDAA PEEQQQPSGG EMVDYMLGQP QAHHHAAAAS  60
QQQQPITQNQ MSSLDKLSFS DVLHFADFGP KLALNNNRSA VPCRRVASSS RIIMWWSRKR  120
AARLPPKAGK SGGGRRKRPR TVKTSEEVES QRMTHIAVER NRRRQMNEYL RVLRSLMPGS  180
YVQRGDQASI IGGAIEFIRE LEQLIQCLES QKRRRLYGDA PRPPLVADAT AGAGAPPSIQ  240
QPQPPPFFSP SLPFPTASGG SGGSDGGAAK ILDLDVVGAA GGLGNREELA ENKSCLADIE  300
VRALGPDAMI KILSRRRPGQ LIKTIAALEE MQMNILHTNV TTIEQTVLYS FNVKIAGDAR  360
FSAEDIAGAV HQILSFIDIN YTI*
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1117137RKRAARLPPKAGKSGGGRRKR
2151162RMTHIAVERNRR
3211215KRRRL
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapOropetium_20150105_03723A
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008656087.11e-157transcription factor FAMA isoform X2
SwissprotQ56YJ84e-99FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A3L6DLR81e-154A0A3L6DLR8_MAIZE; Transcription factor FAMA
TrEMBLK7UXU61e-154K7UXU6_MAIZE; BHLH transcription factor (Fragment)
STRINGGRMZM2G162450_P011e-155(Zea mays)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP95023340
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.14e-94bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]