PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Ote100275380041
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Ocimeae; Ocimum
Family E2F/DP
Protein Properties Length: 464aa    MW: 51695.4 Da    PI: 6.001
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Ote100275380041genomeOteDB-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP83.12.3e-26156221171
                       E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                                   r+++sL llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Ote100275380041|100275380041 156 RYDSSLSLLTKKFIALIKHAEDGELDLNKAADTL---QV--QKRRIYDITNVLEGIGLIEKKLKNRIHWKG 221
                                   6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.3E-28153223IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467858.5E-17156219IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.0E-33156221IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.9E-24158221IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440742.07E-18236323No hitNo description
CDDcd146604.94E-26237323No hitNo description
PfamPF164211.3E-13237321IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 464 aa     Download sequence    Send to blast
MAARGTPSRD AAATPSAAAS NGQILHQQQT PPPAIRRHLP FASMKPPFVS PGDYHRFSTX  60
XXXXXXXXXH LSEAIVIKSP PFKRKNGYQN NEVESSEWTA SPVYSDIANS PFRTPVSAKG  120
RATSRSKATK NNRSVPSTPI SNVDAPSPLT PASSCRYDSS LSLLTKKFIA LIKHAEDGEL  180
DLNKAADTLQ VQKRRIYDIT NVLEGIGLIE KKLKNRIHWK GLDPSRPGEV DKDGTLLHAE  240
IENLSMEERS LDERIRQMQE KLRNLSEDEN NQRWLFVTED DIKNLPCFQL SKHPMGPPSK  300
FQILMRIILR STMGPIDVYL VSQFEEKFEE MNGVDNSTNF PVASSSGSHE NLAVDRSPLA  360
HEPPQFETHT REIHGLDSGY GSSQEYPGGM TRIIPSNIDN DADYWLLSDA DISITDMWKT  420
DTGVEWNDVN MLHDELEMAG ISTPRAHIPA SGVADVHPVD NVQP
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A5e-24151224276PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011094221.10.0transcription factor E2FA
SwissprotQ9FNY01e-119E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A4D9AXF60.0A0A4D9AXF6_SALSN; Uncharacterized protein
STRINGMigut.J00719.1.p0.0(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]