PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Ote100136550091
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Ocimeae; Ocimum
Family E2F/DP
Protein Properties Length: 371aa    MW: 41032.6 Da    PI: 4.5508
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Ote100136550091genomeOteDB-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.61.8e-2794159171
                       E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                                   r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Ote100136550091|100136550091  94 RYDSSLGLLTKKFINLIKHAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKIKNRIQWKG 159
                                   6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.8E-2992161IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013727.4E-3594159IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.09E-1794157IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.2E-2496159IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440744.71E-33173276No hitNo description
PfamPF164212.5E-33176274IPR032198E2F transcription factor, CC-MB domain
CDDcd146601.02E-41187276No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 371 aa     Download sequence    Send to blast
MKHINPLCEN LRENSLETLK RKPGVTGSEV EPSDHNAGPG NIAHVTGPFQ TPPSAKSGKL  60
QKAPKAKANK VSLIAMTNVG SPSGNNLTPV GPCRYDSSLG LLTKKFINLI KHAEDGILDL  120
NKAADTLEVQ KRRIYDITNV LEGIGLIEKK IKNRIQWKGL DVSKPGEVDE SLPGIQEEIE  180
NLNIEERKLD ERIREMQEKL RGLSEDENNQ RWLFVTEEDI KCLPCFQNET LIAIKAPHGT  240
TLEVPDPDEA VDYPQRRYRI VLRSTMGPID VYLVSQFEEN FEEINAVEEQ ACIPETPSAN  300
NNTSAPSSRL EIGGDETAAQ GVETQRMCSE ASTSQDFVSG ILKIVPEVDS DADYWLLSDA  360
DXXXXXXTCG A
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A6e-2789160274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011090314.10.0transcription factor E2FB isoform X1
SwissprotQ9FV711e-131E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A4D9AN860.0A0A4D9AN86_SALSN; Uncharacterized protein
TrEMBLA0A4D9BWW90.0A0A4D9BWW9_SALSN; Uncharacterized protein
STRINGMigut.N02463.1.p0.0(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]