PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Ote100136550081
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Ocimeae; Ocimum
Family E2F/DP
Protein Properties Length: 296aa    MW: 33113.6 Da    PI: 4.1936
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Ote100136550081genomeOteDB-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP87.11.2e-271984171
                       E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                                  r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Ote100136550081|100136550081 19 RYDSSLGLLTKKFINLIKHAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKIKNRIQWKG 84
                                  6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.6E-291786IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.18E-171982IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013727.4E-351984IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023198.4E-252184IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440743.14E-3398201No hitNo description
PfamPF164211.6E-33101199IPR032198E2F transcription factor, CC-MB domain
CDDcd146601.12E-41112201No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 296 aa     Download sequence    Send to blast
MTNVGSPSGN NLTPVGPCRY DSSLGLLTKK FINLIKHAED GILDLNKAAD TLEVQKRRIY  60
DITNVLEGIG LIEKKIKNRI QWKGLDVSKP GEVDESLPGI QEEIENLNIE ERKLDERIRE  120
MQEKLRGLSE DENNQRWLFV TEEDIKCLPC FQNETLIAIK APHGTTLEVP DPDEAVDYPQ  180
RRYRIVLRST MGPIDVYLVS QFEENFEEIN AVEEQACIPE TPSANNNTSA PSSRLEIGGD  240
ETAAQGVETQ RMCSEASTSQ DFVSGILKIV PEVDSDADYW LLSDADXXXX XXTCGA
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-271485274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011090314.10.0transcription factor E2FB isoform X1
RefseqXP_020552667.10.0transcription factor E2FB isoform X2
SwissprotQ9FV711e-124E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A068UEG01e-166A0A068UEG0_COFCA; Uncharacterized protein
STRINGMigut.N02463.1.p1e-164(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]